Amaç: Son zamanlarda, preoperatif sistemik enflamatuar yanıtın kolorektal kanserli hastalarda (CRC) prognostik bir faktör olduğu bildirilmiştir. Bu bağlamda preoperatif nötrofil lenfosit oranı (NLO), prognoz için faydalı bir öngörü faktörü olarak öne sürülmüştür. Bu çalışmada nötrofil/ lenfosit oranının kolorektal kanser nedeniyle cerrahi tedavi uygulanan hastalarda postoperatif komplikasyonları öngörebilmedeki klinik değerini ve prognostik önemini saptamayı amaçladık. Yöntem: 2015-2019 yılları arasında kolorektal kanser nedeniyle cerrahi tedavi, uygulanan hastalar çalışmaya dahil edili. Grup 1 (NLO düşük) ve grup 2 (NLO yüksek) olmak üzere iki grup oluşturuldu. Gruplarda hastaların demografik ve klinik özellikleri intraoperatif ve postoperatif sonuçlarları ortalama sağkalımları karşılaştırıldı. NLO belirlenen cut off değerinde postoperatif komplikasyonları öngörebilmedeki değerine bakıldı. Bulgular: Hastalar 2,08 cutoff değerine göre iki gruba ayrıldı grup 1=56 hastadan grup 2=223 hastadan oluşuyordu Her iki grupta da erkek cinsiyet baskındı (%60 vs,%64 p=0,349), grup 2'deki hastalar daha çok neoadjuvant tedavi almıştı (%29,1 vs %12,5 p=0,007), intraoperatif komplikasyon ÖZ Aim: Recently, the preoperative systemic inflammatory response has been reported to be a prognostic factor in patients with colorectal cancer (CRC). In this context, the preoperative neutrophil/lymphocyte ratio (NLR) has been proposed as a useful predictor of prognosis. In this study, we aimed to determine the clinical value and prognostic significance of neutrophil/lymphocyte ratio in predicting postoperative complications in patients undergoing surgical treatment for colorectal cancer. Method: Patients who underwent surgical treatment for colorectal cancer between 2015-2019 were included in the study. group 1 (Low NLR) and group 2 (High NLR) were formed. Demographic and clinical characteristics, intraoperative and postoperative results, and mean survival were compared. The value of NLR in predicting postoperative complications at the determined cutoff value was examined. Results: Patients were divided into two groups according to the cutoff value of 2.08. Group 1 consisted of 56 patients, and group 2 consisted of 223 patients. Male sex was dominant in both groups (60% vs 64%, p=0.349), while patients in group 2 received more neoadjuvant treatment (29.1% vs 12.5%, p=0.007). Intraoperative complication rates were similar (1.8% vs 4%, p=0.369), pathological grade (p=0.031), and stage (p=0.113) were similar. Postoperative complications were more common in group 2 (24.7% vs 10.7%, p=0.015). Total survival was shorter in group 2 (46 months vs. 52 months, p=0.025). At the determined cutoff value, NLR predicted postoperative complications with 22.94% specificity and 90.6% sensitivity. Conclusion: High NLR was associated with postoperative complications and survival. Although it has a prognostic value, its value in predicting postoperative complications is limited and cannot be used alone.
The aim of this study was to evaluate the early results of laparoscopic gastrectomy performed in a university clinic. Materials and Methods: Laparoscopic gastrectomy performed between September 2015 and September 2018 were divided into two groups as total and distal, and evaluated in terms of the technical, pathological and early postoperative complications. Results: Eighteen patients (11 male and 7 female) were included in the study. The mean age was 57.4 and the mean BMI was 26.3. Surgical treatment was prioritised in 13 patients and only five patients underwent neoadjuvant treatment protocols. Total gastrectomy was the preferred surgical method in 14 patients and distal gastrectomy in 4 patients. All patients underwent standard D2 lymph dissection according to tumor localization and 33.2 was the mean number of lymph nodes dissected in the total gastrectomy group; while a mean of 32 lymph nodes were dissected in the distal gastrectomy group. The mean oral start time was 6.4 days in the total gastrectomy group and 2.5 days in the distal gastrectomy group. Duodenal stump leak was detected in 4 patients, esophagojejunostomy leak was detected in 2 patients, while 1 patient had bleeding in the drain location. Conclusion: There are many studies demonstrating the adequacy of laparoscopic gastrectomy and lymphatic dissection. However, we believe that as the experience increases in these surgeries with many technical difficulties and a long learning duration; the operation time will be shortened and the complication rate will decrease. Amaç: Bu çalışmada bir üniversite kliniğinde gerçekleştirilen laparoskopik gastrektomilerin erken dönem sonuçlarının paylaşılması amaçlanmıştır. Gereç ve Yöntem: Eylül 2015-Eylül 2018 tarihleri arasında yapılan laparoskopik gastrektomiler total ve distal olmak üzere iki gruba ayrılmış, teknik, patolojik sonuç ve erken postoperatif komplikasyonlar açısından incelenmiştir. Bulgular: Çalışmaya 11'i erkek, 7'si kadın olmak üzere 18 hasta dahil edilmiştir. Yaş ortalaması 57,4 olup, ortalama BMI 26,3 idi. 13 hastada cerrahi ilk planda tutulmuş sadece beş hastaya neoadjuvan tedavi protokolü uygulanmıştır. Total gastrektomi 14 hastada, distal gastrektomi 4 hastada tercih edilen ameliyat yöntemidir. Tüm hastalara tümör yerleşimine göre standart D2 lenf disseksiyonu uygulandı ve Total gastrektomi grubunda Ortalama 33,2 distal gastrektomi grubunda 32 lenf nodu disseke edildi. Ortalama oral başlama süresi ve Total gastrektomi grubunda 6,4 gün distal gastrektomi grubunda 2,5 gün idi. Duodenal güdük kaçağı 4 hastada, özefagojejunostomi kaçağı 2 hastada tespit edilirken 1 hastada da dren yerinde kanama görüldü. Sonuç: Laparoskopik gastrektomi ve lenfatik disseksiyonun yeterliliğini gösteren birçok çalışma bulunmaktadır. Ancak öğrenim süreci uzun, teknik zorlukları fazla olan bu ameliyatlarda deneyim ve tecrübe arttıkça ameliyat sürenin kısalacağını ve komplikasyon oranının azalacağını düşünmekteyiz.
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