In subgroups of breast cancer, the shortest disease-free and overall survival was observed in basaloid and human epidermal growth factor receptor-2 groups. CK5/6 expression is a marker used in diagnosing breast cancers in basaloid group and is associated with a poor prognosis. Similarly, loss of tumor suppressor gene PTEN and a high expression of c-Met has been associated with poor prognosis in breast cancer and many other cancers. In this study, we aimed to determine the effect of CK5/6 and c-Met expressions, and PTEN loss on the disease prognosis in triple-negative breast cancer patients. Ninety-seven patients pathologically diagnosed with triple-negative breast cancer were enrolled. The clinical and pathological characteristics of the patients were recorded. c-Met, PTEN, and CK5/6 expressions were evaluated with immunohistochemical methods from paraffin blocks. The median age of patients was 47 years. CK5/6 positivity was 50.5 %, PTEN loss was 44.3 %, and high c-Met expression was detected in 53.6 %. In multivariate analysis, predictors of the recurrence were loss of PTEN (HR = 2.99; P = 0.004), high c-Met expression (HR = 2.05; P = 0.06), CK5/6 expression (HR = 2.99; P = 0.02), increase in the number of metastatic lymph nodes (HR = 1.11; P = 0.001), and an increase in tumor size (HR = 1.226; P = 0.01). Also, PTEN loss (HR = 2.43; P = 0.05), CK5/6 expression (HR = 3.74; P = 0.01), and N2-3 tumors compared to negatives (HR = 3.63; P = 0.01) were associated with death. PTEN loss correlated with those of lymphovascular invasion. There was a correlation between CK5/6 expression and the number of metastatic lymph nodes. Also, a correlation was found among cancers with highly expressed levels of c-Met, T1-2 tumors, and high-grade tumors. The classical markers, lymph node involvement and tumor size, were found to be of prognostic value; however, high c-Met and CK5/6 expressions, and PTEN loss were found to increase risk of recurrence and death in patients with triple-negative breast cancer.

Asian Pac J Cancer Prev, 15 (15), [6449][6450][6451][6452][6453] Introduction Non-small cell lung cancer (NSCLC), which includes a broad range of lung tumors encompassing squamous cell carcinomas and adenocarcinomas as the major subtypes, is the most common cause of cancer related death (Jemal et al., 2010). In patients with lung adenocarcinoma, only a few parameters are described as a prognostic factors such as stage of disease, tumor metabolism, high GLUT1 expression and performance status (de Geus-Qei et al., 2007;Andersen et al., 2011).Serum total proteins contain albumin, globulins and other inflammatory proteins such as C-reactive protein (CRP), interleukins and tumor necrosis factors (McPherson et al., 2006). Albumin and globulins play a pivotal role in the inflammatory process . Serum albumin is also an objective parameter that reflects the degree of long-term nutrition status (Laky et al., 2007

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Bu araştırma okul öncesi öğretmen adaylarının üstün yetenekli çocuklara ilişkin metaforik algılarını ortaya koymak amacıyla gerçekleştirilmiştir. Nitel bir araştırma olan bu çalışmada olgubilim deseni kullanılmıştır. Bu araştırma Anadolu'daki bir üniversitenin okul öncesi öğretmenliği bölümünde okuyan toplam 115 öğretmen adayının katılımı ile gerçekleştirilmiştir. Araştırma sonucuna göre, öğretmen adayları toplamda 87 farklı metafor üretmişlerdir. Öğretmen adaylarının kullandıkları en fazla metafor 'hazine olmuştur. Erkek öğretmen adaylarının 'üstün yetenekli çocuk'larına ilişkin algıları en çok 'teknoloji' ve 'değer' kategoride toplanmıştır. Birinci sınıfta öğrenim gören öğretmen adaylarının en fazla 'değer' kategorisine ait metaforları ürettikleri dördüncü sınıf öğretmen adaylarının ise 'değer' ve 'insani özellik' kategorilerinde metafor oluşturdukları görülmüştür.