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To compare the effects of testosterone on intraocular pressure (IOP), retinal nerve ber layer thickness (RNFL), ganglion cell complex (GCC), macular thickness (MT), and ocular blood ow between female-tomale transgender (FMT) persons who use testosterone and healthy women and healthy men. MethodThe study included 39 eyes of 20 FMT(group 1), 40 eyes of 20 healthy women (group 2), and 42 eyes of 21 healthy men (group 3). In all subjects, RNFL, GCC, MT were measured by optical coherence tomography (OCT). Ocular blood ow was measured by Colour Doppler Ultrasonography in all subjects. ResultsIOP levels in FMT were signi cantly higher than men (p = 0.02). Para superior (Sup), Para inferior (Inf) and Peri nasal (Nas) thickness in FMT were signi cantly higher than the group 2 (p = 0.02, p = 0.03, p = 0.01). Peri Sup thickness in FMT was signi cantly higher than group 3 (p = 0.01). Peri Inf thickness in FMT was signi cantly higher than group 2 and 3 (p = 0.03, p = 0.002). Mean thickness of RNFL Inf in FMT was signi cantly higher than the group 2 and 3 (p = 0.03, p = 0.03). Avg GCC, Inf GCC in FMT were signi cantly higher than group 2 (p = 0.02, p = 0.005). In correlation test, systole/diastole ratio(S/D) in Ophthalmic artery (OA) (r = 0.504, p = 0.028) and Inf RNLF thickness (r = 0.485, p = 0.035) were positively correlated with the serum levels of testosterone in FMT. ConclusionsWe found that the use of supraphysiologic testosterone dose increased IOP and the thickness of macula, RNFL and GCC in FMT. Serum testosterone level was positively correlated with S/D ratio in the OA.

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