Background: Antenatal Care (ANC) is a health service that is conducted to monitor and support the health of the mother and fetus and detect the presence of disorders during pregnancy and prevent complications. An ANC visits are said to be compliant if pregnant women make ANC visits at least six times. Anc's visit in Ambon City showed a decrease from 2019 to 2020. This study was conducted with the aim of finding out if there is a relationship between the level of knowledge and attitude of pregnant women with compliance with ANC visits at Rijali Health Center in 2021.Method: This type of research is analytical with a cross-sectional approach with a sample number of 140 using consecutive sampling techniques. The analysis used in this study was a univariate and bivariate analysis using the chi-square test.Results: The results of this study obtained the percentage of respondents who obediently conducted an ANC of 74.3% and non-compliant by 25.7%.Conclusion : Based on the results of the chi-square test there is a relationship between knowledge (p = 0.007) and compliance with ANC visits at Rijali Health Center and there is no relationship between attitude (p = 0.745) and compliance with ANC visits at Rijali Health Center. Thus this study demonstrates the importance of knowledge and attitude in carrying out an ANC visit.