<p>ABSTRACT<br />Objective: To isolate and identify aerobic microbes present in the periodontal infected patients and to evaluate the choice of antibiotics in the<br />management of periodontal diseases.<br />Methods: In this study, these patients have not been treated previously for their conditions. An informed consent was obtained from these patients<br />before collection of an oral swab. This study was approved by the Institutional Ethical Committee. The details of the patient’s age, sex, and clinical<br />details were recorded on a per forma meant for this study. The following methodologies were adopted for the isolation and identification of the microorganisms<br />from<br />these cases.<br />Results: In this study out of 50 oral samples, culture positivity was recorded in 43 (86%) cases and no growth in 7 (14%) cases. Antibiotic susceptibility<br />test using to identified as resistant, sensitive, intermediate of pathogenicity of oral microbes. Such antibiotics were methicillin, ceftazidime,<br />clindamycin, amikacin, cloxacillin, and cefotaxime. This study should be kept in mind when a local application of antibacterial compounds is used in<br />the therapy of periodontal disease.<br />Conclusion: This study highlights the different organisms involved in the different types of dental infections. The antibiotic pattern shown in this work<br />will be a guide to the clinician in the selection of proper antibiotics for the treatment of these infections. Hence in this study, the limitations were time<br />and the number of patients. For better outcomes, a larger study population for a longer period of time should be undertaken to know the bacteriology<br />and to the select the effective drugs of choice for dental infections. A comparative study of bacteriology and mycology and its antimicrobial property<br />would be very fruitful in the future.<br />Keywords: Dental, Periodontal, Bacteria, Antibiotics.</p>