The low performance of the Regional Special Hospital belonging to the Province of South Sulawesi illustrates the quality of consumer services that affect hospital income. This study aims to analyze the effect of job satisfaction on organizational performance, the effect of organizational commitment on organizational performance, the effect of job satisfaction on organizational commitment, and the effect of job satisfaction on organizational performance directly and indirectly through organizational commitment of the Mother and Child Hospital of South Sulawesi Province. This type of research is a quantitative study using an analytical observational study with a cross sectional study design. The sample was taken using stratified random sampling so that the sample in this study included medical, nursing, midwifery and non-medical personnel, totaling 190 respondents at the Siti Fatimah Mother and Child Hospital and Mother and Child Hospital Mother and Child Motherland, South Sulawesi Province. The results showed that there was a relationship between job satisfaction and organizational performance (0.000), there was a relationship between organizational commitment and organizational performance (0.000), there was a relationship between job satisfaction and organizational commitment (0.000), and job satisfaction was the most influential variable on performance (32, 10%) compared to organizational commitment (21.90%). Therefore, it is expected that the hospital is able to maintain and develop the supporting dimensions of job satisfaction and organizational commitment of its employees in order to achieve organizational performance as expected.