The purpose of this study was to determine the differences in the mathematical resilience of male and female students using Google Classroom-based scientific learning. This research was conducted at SMA Negeri 1 Kopo even semester in the 2019-2020 school year. The method used was a qualitative descriptive method using a questionnaire in the form of an online survey via Google form. The questionnaire was given to students who were learning online in mathematics. The population taken was all students of class XI MIA SMA Negeri 1 Kopo. Sampling using a purposive sampling technique that was a technique of determination and sampling determined by the researcher with certain considerations. The sample consisted of 30 students. The research instrument consisted of 20 statements that refer to indicators of resilience. The conclusion obtained was that the average mathematical resilience of male students is greater than female students, with the difference being 0.715 for male students and 0.713 for female students.