Background: Globally, colorectal cancer is the third most common cancer among men and the second most common among women. Colorectal cancer is the fourth most frequently diagnosed cancer, but the second-leading cause of cancer deaths. Incidence of colorectal cancer has decreased significantly in recent decades, mortality rates have fallen as well. Those declining rates are largely attributed to earlier diagnosis through screening and more sophisticated and effective methods of treatment. Objective: That work represents colorectal cancer metastasis management, early detection and screening of colorectal cancer. Subjects and Methods: This observational study was conducted on 10 patients with liver metastasis admitted to GIT Surgery Unit, Cancer National Institute and postoperative follow up and observation at El-Haram Hospital and Cancer National Institute between April 2017 and December 2017. Results: This work is observational study. The patients in this study were divided into two (2) groups: group 1 and group 2. The included patients were prepared through studying the patient's condition, preoperative & intraoperative assessment. Choice of operation and how to manage synchronous metastases. The type of resection does not seem to influence the prognosis if a clear margin is obtained. The carcinoembrionic antigen (CEA) level is strongly correlated with recurrence-free survival. A free margin of at least 1 cm offers the best chance of avoiding recurrence. Conclusion: In this work observational study results preoperative, operative and postoperative results were recorded. Operative results (type of surgery, surgical technique), postoperative results (liver related complications, general complications, and postoperative morbidity and mortality of liver resection of colorectal cancer. Prognosis and follow up of patients of study and postoperative recurrence.