The aim of this study was to detect the comparative pathological affections in kidneys of cattle and sheep. A total number of 192 kidney samples showing different pathological lesions were collected from El-basatin abattoir in Cairo-Egypt; 69 samples were collected from cattle and 123 samples were collected from sheep, respectively. Microscopically, the highest incidence of occurrence of renal interstitial nephritis was found to be 17.39% in cattle and 28.45% in sheep, followed by glomerulonephritis 21.73% in cattle and 25.20% in sheep; circulatory disturbances were 15.94% in cattle and 16.3% in sheep; suppurative nephritis were 11.59% in cattle and 13.00% in sheep; amyloidosis was 7.24% in cattle while in sheep was 13.20%;. Meanwhile, neoplasms were detected in 3.25% cases collected from sheep. Moreover, parasite, stones, polycystic kidney, hydronephrosis and acute necrotic nephritis were observed in few cases of cattle as 2.89%, 7.24%, 2.89%, 8.69% and 4.34% respectively. Detailed gross and microscopical findings in each lesion were described. Inflammatory conditions in the kidneys were a common finding in both cattle and sheep. However, parasitic infestation is not a common finding in renal lesion.

No abstract

Background/aim: Liver cirrhosis is a common health problem that is mostly at the late stage associated with hepatic carcinogenesis. This study aimed to clarify the sequential proliferative lesions in the cirrhotic liver induced chemically by thioacetamide (TAA) in rats. Methods: Thirty male albino rats were equally divided into control and TAA groups. In the TAA group, rats were intraperitoneally injected with 100 mg/kg TAA twice /week for 18 weeks. Animals were euthanized after 6, 12, and 18 weeks. Blood and liver samples were collected for biochemical analysis and histopathological examination. Results: TAA-treated group had significantly increased serum levels of liver damage parameters (alanine transaminase, aspartate transaminase, and alkaline phosphatase), and hepatic levels of oxidative stress-related markers (malondialdehyde and nitric oxide) as compared to the control group. Meanwhile, the TAA group showed significantly decreased hepatic levels of antioxidant markers (reduced glutathione and superoxide dismutase) relative to the control group. Histopathological examination of the liver revealed characteristic lesions of liver cirrhosis in form of regenerative nodules, the proliferation of bile ducts epithelium and hepatic stellate cells as well as different types of foci of cellular alterations which were prominent proliferative lesions in the liver of the TAA group. However, with TAA prolonged treatment, cellular atypia and preneoplastic changes became evident in many hepatocytes. Immunohistochemical expression for Ki67 revealed positive nuclear labeling in some hepatocytes of TAA-treated rats. Marked expression for Ki67 in regenerating nodules at 18 weeks following TAA treatment was interesting as it revealed a higher regeneration activity. Conclusion: Some proliferative lesions such as regenerative nodules and foci of cellular alteration in hepatic cirrhosis may later constitute carcinogenic development.