Diabetes mellitus (DM) is associated with hyperglycemia, abnormal lipid profiles and inflammatory disorders. The extracts from leaves of Moringa oleifera or beans of green coffee were found to treat metabolic disorders as good sources of polyphenols and flavonoids. Also, coffee is a rich source of dietary antioxidants and chlorogenic acid. The present study aimed to evaluate the protective effect of the ethanolic extract of Moringa oleifera (MO) and beans of green coffee (GC) in alloxan induced diabetic rats, the stress oxidant, hepatic-kidney dysfunction and histological changes in liver and kidneys of different experimental groups of rats. The extracts were administered using the gastric tube of rats. Results ascertained that orally administration with ethanolic extract of green coffee beans and Moringa leaves significantly reduced serum glucose level (P < 0.05), improved serum lipid profiles, liver function enzymes and kidney functions in diabetic rats after 28 days. Histological sections of the liver and kidney tissues showed the protective effects of MO and GC in the treated rats. It is noteworthy that there is a synergistic effect between Moringa leaves and green coffee beans.