Results 130 medicines were reviewed in 79 patients from January to August 2020. Mean age was 61±6.5 years. 48 patients (60.78%) were polymedicated; the average number of medications per patient was 4.25. At the pharmacokinetic level, the main interaction was CYP3A4 substrate concentrations were increased, and at the pharmacodynamic level, the risk of QT syndrome and serotoninergic syndrome were increased. 61 PDI were founded in 40 patients (51.89%); 10 were severe and 21 were moderate. The most common types of drugs involved were steroids, proton pump inhibitors and antidepressants. Eight (80%) severe PDI were accepted and moderate recommendations led to reduction in dosage or concomitant use. Conclusion and relevance This study showed that more than half of patients with NEPA has at least one PDI. Clinical pharmacists are essential in detecting PDI, which is a positive influence on physician prescriptions and patient treatment outcomes, improving the safety and effectiveness of oncological treatment

Other side effects were hypertransaminasaemia (33.92%; 19), hyperbilirubinaemia (5.36%; 3), anaphylaxis (5.36%), capillary permeability syndrome (5.36%), alteration of renal function (1.78%; 1) and rash (1.78%). Conclusion and relevance ATG treatment in paediatric patients was associated with mild side effects. ATG triggered analytical and clinically altered parameters that simulated infection and hence empirical antibiotherapy was initiated which could be stopped precociously in the event of toxic fever by ATG.