Background and Purpose The endovascular clip system (eCLIPs) is a novel device with both neck bridging and flow diversion properties that make it suitable for the treatment of wide-necked bifurcation aneurysms. We aim to describe the clinical and radiologic outcomes of the eCLIPs device, including the first-in-man use of the latest version of the device. Materials and Methods This is a retrospective case series on all the wide-necked bifurcation aneurysms treated with the eCLIPs device in our center. The immediate and latest radiologic and clinical outcomes were assessed. Results The device was successfully implanted in 12 out of 13 patients. After a median follow-up period of 19 months (Range: 3 months-64 months), all patients with available data (11/12) had a good radiologic outcome (Modified Raymond-Roy Classification scores of 1 or 2). Two patients (18.1%) underwent retreatment with simple coiling through the device. One of these had a subarachnoid hemorrhage prior to retreatment. There were no major complications (death or permanent neurologic deficits) associated with the use of the device.