We present a case of late acute myopia syndrome following discontinuation of treatment with a combination of sulphonamide drugs. To the best of our knowledge, this is the first reported case with such a presentation, and suggests that the pathophysiological basis for the acute myopia syndrome is a rapid decrease in serum carbonic anhydrase inhibitors levels which may lead to a rebound increase in the production of aqueous humor and accumulation of suprachoroidal fluid. It is further postulated that there may be a cumulative effect of sulphonamide drug use on carbonic anhydrase activity in the ciliary body epithelium of susceptible individuals.

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Tritiated leucine injected into the vitreous of experimental animals was used for detection of the dynamics of axonal transport in the optic nerve in eyes with elevated intraocular pressure (IOP). Direct quantitative evaluation of axonal transport was performed by means of the liquid scintillation counter. Our results show that topical instillation of beta-blockers, pilocarpine and epinephrine have the most positive influence on the dynamics of axonal transport in eyes with increased IOP. There was a zero or negative influence of physostigmine, neostigmine, echothiophate and partially of clonidine (isog-laucon).

The aim of the study was to evaluate the effect of human immunodeficiency virus infection on the retinal nerve fibre layer. The thickness was assessed in 48 human immunodeficiency virus-positive patients using scanning laser polarimetry. Results were compared to normal values and tested against factors suspected to affect the retinal nerve fibre layer. The mean value of the thickness was 57.65 ± 6.18 µm in our cohort. No significant correlation between the retinal nerve fibre layer thickness and the immune profile or antiretroviral therapy was detected. However, a significant negative correlation between the retinal nerve fibre layer thickness with increasing length of human immunodeficiency virus infection was found. Keywords: HIV, retinal nerve fibre layer thickness, scanning laser polarimetry Neuroophthalmology Downloaded from informahealthcare.com by Radboud Universiteit Nijmegen on 11/17/14 For personal use only. Neuroophthalmology Downloaded from informahealthcare.com by Radboud Universiteit Nijmegen on 11/17/14 For personal use only.