The first enantioselective total synthesis of scopadulcic acid A is described. The key step is a cascade
intramolecular Heck reaction of a methylenecycloheptene iodide, which generates the B, C, and D rings of the
scopadulan ring system in 90% yield as a single stereoisomer. A distinctive feature of these syntheses is the
use of stereoselective enolization to dictate which enantiomer of the natural product is produced.
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