Background: The May-Grünwald Giemsa Stain is one of the preferred Romanwsky stains in studying cell morphology of air-dried smears with respect to cellular and nuclear size details and metachromatic extracellular ground with an approximate staining time of 20–30 min. A reduction in staining time and possible application of an ultrafast stain for rapid onsite evaluation (ROSE) of cytological material is the need of the hour. With the application of the new modified ultrafast Giemsa (MUFG) technique, rapid staining can be achieved, thereby helping in triaging of samples and, most importantly, providing an early preliminary diagnosis. Aims: The aim is to assess the quality index of the MUFG technique in FNAC of various organs in comparison with the standard MGG stain. Materials and Methods: A total of 61 FNAC cases were studied by random sampling. Two smears were prepared for each case and stained by both. Scores were given based on five parameters, and the quality index was calculated. Statistical Analysis: Results were analyzed using mean, median, standard deviation, “ t ” paired test, “ P ” value, and M-diff for statistical significance. Results: The quality index of MUFG smears was comparable to the standard MGG stain in salivary gland, breast, and thyroid aspirates and low in lymph node and soft tissue aspirates. MUFG is a rapid cost-effective stain which can be applied in the setting of ROSE for a preliminary diagnosis. Conclusion: MUFG is a reliable alternative and rapid technique for cytology diagnosis.

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Malignant bone tumors with epithelial differentiation are extremely rare. A primary carcinosarcoma arising in bone is characterised by the presence of both epithelial and mesenchymal differentiation. Herein we report an extremely rare case of primary chondroblastic osteosarcoma with true divergent glandular differentiation in a twenty-nine year old female. Microscopic sections reveal a high-grade chondroblastic osteogenic sarcoma with definite areas showing neoplastic osteoid formation and nests, cords and acinar (glandular) structures with cytokeratin positivity suggesting definitive epithelial glandular differentiation. Our case illustrates the ability of osteosarcomas to show epithelial differentiation characterized both by cytokeratin expression and differentiation to adenocarcinomatous cells displaying distinct glandular differentiation

Solid pseudopapillary neoplasm (SPN) is a rare histopathologic variant of pancreatic tumors. Franz first described this tumor as a “papillary tumor of the pancreas, benign or malignant.” In 1996, the World Health Organization named this tumor as SPN of the pancreas. It has a female preponderance with a male-to-female ratio of 1:9. A 30-year-old female who is a known case of lymphocyte-rich classic Hodgkin's lymphoma underwent 18F-fluoro-2-deoxy-D-glucose (FDG) positron-emission tomography/computed tomography (PET/CT) for initial staging which showed intense metabolic activity in bilateral enlarged cervical and splenic hilar lymph nodes. Furthermore, intense metabolic activity was noted in hypodense lesion in the tail of the pancreas, and she was reported to be having Stage IIIE disease. Post chemotherapy, 18F-FDG PET/CT showed disappearance of all previously metabolically active lymph nodes but persisting metabolically active lesion in tail of the pancreas. Hence, we reported as complete metabolic response of Hodgkin's lymphoma as per the Lugano criteria with suspected synchronous primary in the tail of the pancreas. Post distal pancreatectomy, histopathological examination and immunohistochemistry revealed the pancreatic lesion as SPN. SPN of the pancreas itself is a rare tumor and the presence of SPN in a patient with Hodgkin's lymphoma as synchronous primary is very rare. Due to the high density of mitochondria and the hypervascular nature of the tumor, there is an accumulation of 18F-FDG in SPN tumor cells. Patients with SPN usually have a very good prognosis after surgery. The five-year survival rate is as high as 95%–97%.