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difference was found in mean change in Hgb (3.4 ± 1.9 vs. 3.2 ± 2.1; p=0.789), patients requiring transfusion (6 vs. 5%; p=1.000), postoperative bleeding requiring surgery (0 vs. 0%; p=1.000), infection within 90 days postoperative (2 vs. 0%;p=0.217), or median LOS in days (14, 7-40 vs. 13, 9-16; p=0.622). No deaths occurred. A significant increase in DVT within 90 days postoperative was found in the TXA arm (36.4 vs. 0%; p=0.037). Conclusions: In this pilot study, TXA showed a non-significant reduction in intraoperative blood loss and was associated with an increased incidence of DVT. Ongoing assessment is planned to confirm these initial findings.Learning Objectives: Sedative is often administered to maintain hemodynamics and pulmonary function after cardiovascular surgery. Especially, after emergency cardiovascular surgery, sedative is routinely administered to maintain hemodynamics in order to control postoperative bleeding. Dexmedetomidine (DEX), a new sedative and alpha-2 adrenoceptor agonist, is reported to expert superior hemodynamic-control and organ-protective properties compared with other sedatives. Therefore, we hypothesized that DEX, as compared with propofol only, would provide greater improvements in critical patients after emergency cardiovascular surgery. Methods: Forty-two patients (M/F 28/14, mean age 60 yr) after emergency cardiovascular surgery, underwent the sedation of DEX in addition to propofol (DEX group). The DEX administration was undergone as long as possible. In control group, other 24 patients (M/F 18/6, mean age 62 yr) after emergency cardiovascular surgery were administered only propofol as a sedative. Primary outcome was change in systolic arterial pressure (SAP) and vasodepressor requirement after the sedation, and secondary outcomes were the duration of extubation after surgery, the frequency of occurrence of supraventricular arrhythmia and the change in laboratory data. Results: The combination sedation underwent for mean 58 hr (24-197 hr). SAP and heart rate were maintained in both groups, and vasodepressor requirement in DEX group significantly decreased (42 to 34; p<0.05) after the sedation. After the sedation was stopped, vasodepressor requirement in DEX group increased significantly (8 to 16 drugs: p<0.05). The duration of extubation in the DEX group was significantly shorter than that in control group (5 days vs 8 days; p<0.05). All patients recovered and discharged in ICU. The frequency of occurrence of supraventricular arrhythmia in DEX group is significantly lower than in control. Conclusions: In the present study, the DEX administration maintained hemodynamics and decreased vasodepressor requirement and the frequency of occurrence of supraventricular arrhythmia after emergency cardiovascular surgery.