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An analysis is carried out to study the entropy generation of an incompressible, MHD flow of water based nanofluid over a stretching sheet. The analytical solutions of the governing non-dimensional nonlinear ordinary differential equations are presented in terms of hypergeometric functions and used to compute the entropy generation number. The effects of the physical parameters on velocity and temperature profiles are already studied in our previous work [13]. This work is extended to discuss the effects of magnetic parameter, nanoparticle volume fraction, Hartmann number and the dimensionless group parameter on the entropy generation for Cu, Ag, Al 2 O 3 and TiO 2 nanoparticles. The local skin friction coefficient and reduced Nusselt number are tabulated. MATHEMATICS SUBJECT CLASSIFICATION: 76D10; 76W05; 80A20; 80A99; 82D80 ª 2014 Production and hosting by Elsevier B.V. on behalf of Egyptian Mathematical Society.