Theoretical conceptions on happiness have generally considered two broad perspectives: hedonic enjoyment and eudaemonia. However, most research on how to improve people’s happiness has focused primarily on the enhancement of hedonic happiness. In this longitudinal experimental study we test the differential impact of two positive exercises—Best Possible Selves and the Lottery Question—on hedonic and eudaemonic happiness. The hypothesis that the practice of the Best Possible Selves exercise would increase hedonic happiness was confirmed. This effect was immediate and maintained a week after the exercise. Furthermore, this exercise also increased eudaemonic happiness. However, its effect decreased after a week. Contrary to what was expected the Lottery Question exercise decreased both eudaemonic happiness and hedonic happiness over time. We discuss implications of this study for the literature on positive psychological and behavioral interventions to increase happiness.

Funding Acknowledgements Type of funding sources: None. Introduction Brugada syndrome (BrS) is a channelopathy with high prevalence of malignant arrhythmic events. The risk stratification in patients (pts) with Brugada electrocardiographic (ECG) pattern is of major importance, to prevent sudden cardiac death (SCD). A higher risk is evidenced in spontaneous type 1 pattern when compared with induced type-1 pattern, as so other electrocardiographic features have been explored aiming to detect additional prognostic factors. Purpose To evaluate the association of QRS duration and frequent premature ventricular contractions (PVC) with malignant arrhythmic events. Methods Prospective single-center study of consecutive pts with BrS, with spontaneous or induced type 1 pattern included from 2003 to 2021. All pts were enrolled in a protocol including annual non-invasive assessment with ECG and 24-hours Holter monitoring. Primary endpoints were defined as SCD or appropriate shocks in the context of ventricular tachycardia or fibrillation (VT/FV) during follow-up. Cox regression and Kaplan-Meier survival analyses were used to determine the association between the baseline ECG and Holter characteristics and the long-term risk of arrhythmic events. Results A total of 117 pts was included, 75 (65%) with a spontaneous type 1 pattern and 44 (33%) with an induced type 1 pattern. The mean age was 47±13years and 38 (32.5%) were male. During a median follow-up of 4.1±0.3 years, the primary endpoint occurred in 8 (6.8%) pts, with sudden cardiac death in 3 (2.6%) and appropriate shocks due to VT/FV in 5 (4.3%). Pts who suffered arrhythmic events had presented at the study inclusion higher QRS duration (124±18 vs. 108±16ms, p= 0.014) and more frequent PVCs on 24-hour Holter (169±297 vs. 29±198; p = 0.001) - Figure 1. Indeed, the presence of QRS ≥119ms was associated with a 7-fold higher risk (HR: 7.250, 95% CI 1.619-32.461, p = 0.010) and the presence of more than 6 PVC on 24-hour Holter was also associated with a 5-fold higher risk of malignant arrhythmic events (HR 5.376, 95% 1.186-24.260, p = 0.029). Conclusion QRS duration and frequent PVC may established themselves as additional risk factors. In our cohort, they were both predictors of arrhythmic events during follow-up and thus can further complement BrS risk stratification.

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