One potential alternative material to replace hydroxyapatite (HAp) as a coating material for plasma-sprayed coatings on implants for hip replacement is fluorapatite (FAp). FAp has advantages over HAp regarding the capability of being chemically stable during the coating process. This leads to surface coatings containing high apatite rates with a mechanical stability (bond strength, microhardness) comparable to HAp. From the technical point of view the production of FAp coatings is well investigated, although studies on biocompatibility of FAp coatings are fewer. This paper reports the production of HAp and FAp coatings with varying solubilities by plasma spraying and their in vitro cytotoxicity. Varying solubilities were realized by using modified plasma-spray parameters in common with suitable apatite powders with different crystallinities. Coating solubilities were evaluated by immersing the plasma-sprayed coatings in deionized water and electrolyte solution. Afterwards, cytotoxicity tests were performed using a modified half-slide technique. Cell attachment and cell morphology were evaluated. Neither HAp nor FAp coatings exhibited cytoxic influence on cells in culture. Results suggest that HAp coatings stimulate cell growth and FAp coatings do not. This could be explained by a negative effect on cell growth of the dissolved fluoride ions.