Transplantation allows us to confidently save the lives of previously doomed patients. Unfortunately, this colossal achievement of human progress has a problematic side – the shortage of donor organs. The use of animal organs could solve it. Currently, the issues of xenotransplantation have become relevant again after the experimental xenotransplantation of the kidney of a genetically modified pig in 2021, and the xenotransplantation of the heart in 2022. This practice raises a number of ethical questions. Is it ethical to put humanity at risk by saving one person? Is it ethical to limit the civil rights of a xeno-recipient? Will xenotransplantation create another reason for discrimination? Can the creation of xenochimeras be considered an unacceptable interference in the Divine plan from a religious point of view? Is it ethical to use higher animals for xenotransplantation? Will an increase in the number of xenotransplants create a risk of the identity of the human race? Will xenotransplantation create new questions about equitable organ allocation? The sources of scholars of theologians related to the main Abrahamic religions on this topic are analyzed. Consideration of theological approaches to the new ethical problems presented by xenotransplantation does not allow us to find a unanimity of opinion. However, as this new branch of medical science makes concrete clinical progress, the attitude of society, religious leaders and ordinary believers towards it will improve. From an individual point of view, Judaism does not object to xenotransplantation to prolong and save human life, even in the case of non-kosher animals with genetic modifications. The preservation of life outweighs other values almost without exception. Xenotransplantation, even from a pig, is hailed as a life-sustaining medical intervention from a Jewish ethical perspective by most authors. In Christianity, the motivation is to try to follow the example of Jesus Christ in bringing healing to all those in need. While physiological healing is important, the ultimate goal is the overall well-being of the individual, which requires spiritual, mental, and social well-being in addition to physical health. The most correct generalization about Islamic bioethical views on xenotransplantation would be that, given the state of science, the final ethical and legal definition remains ambiguous, but in general, xenotransplantation as a means of saving human life may be acceptable.

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Цель исследования-изучение вариантной анатомии почечных артерий (ПА) по данным компьютерной томографии с построением трехмерных моделей. Материалы и методы. Исследование основано на построении и анализе 120 результатов мультиспиральной компьютерной томографии с контрастированием ПА. Результаты. 3D-визуализация ПА позволяет прижизненно изучить вариантную анатомию сосудов, спланировать объем операции и доступы. В ходе исследования изучены такие параметры, как добавочные артерии, длина, тип ветвления ПА, количество ветвей и др. Заключение. Использование метода визуализации объема в хирургии почки и почечных сосудов путем создания точных и реалистичных визуальных представлений о ПА является полезным инструментом для планирования оптимальных хирургических подходов и ювелирных результатов вмешательства.

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Fulminant liver failure is usually characterized as severe acute liver injury with encephalopathy and synthetic dysfunction (international normalized ratio [INR] ≥1.5) in a patient without cirrhosis or previous liver disease. Management of patients with acute liver failure includes ensuring that the patient is cared for appropriately, monitoring for worsening liver failure, managing complications, and providing nutritional support. Patients with acute liver failure should be treated at a liver transplant center whenever possible. Serial laboratory tests are used to monitor the course of a patient's liver failure and to monitor for complications. It is necessary to monitor the level of aminotransferases and bilirubin in serum daily. More frequent monitoring (three to four times a day) of blood coagulation parameters, complete blood count, metabolic panels, and arterial blood gases should be performed. For some causes of acute liver failure, such as acetaminophen intoxication, treatment directed at the underlying cause may prevent the need for liver transplantation and reduce mortality. Lactulose has not been shown to improve overall outcomes, and it can lead to intestinal distention, which can lead to technical difficulties during liver transplantation. Early in acute liver failure, signs and symptoms of cerebral edema may be absent or difficult to detect. Complications of cerebral edema include increased intracranial pressure and herniation of the brain stem. General measures to prevent increased intracranial pressure include minimizing stimulation, maintaining an appropriate fluid balance, and elevating the head of the patient's bed. For patients at high risk of developing cerebral edema, we also offer hypertonic saline prophylaxis (3%) with a target serum sodium level of 145 to 155 mEq/L (level 2C). High-risk patients include patients with grade IV encephalopathy, high ammonia levels (>150 µmol/L), or acute renal failure, and patients requiring vasopressor support. Approximately 40 % of patients with acute liver failure recover spontaneously with supportive care. Predictive models have been developed to help identify patients who are unlikely to recover spontaneously, as the decision to undergo liver transplant depends in part on the likelihood of spontaneous recovery of the liver. However, among those who receive a transplant, the one-year survival rate exceeds 80 %, making this treatment the treatment of choice in this difficult patient population.