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A new hybrid haplotype, a DRB1*0103 allele associated with a DRB5*0101 allele, was found in a French Caucasoid family and has been described here. When these cells were typed by serology, contrarily to cells with the DR1 + 2s haplotype, they did not seem to be triplets. The reactivity of these cells with the DR2 allosera led to a false serological HLA-DR typing. RFLP analysis and DNA oligotyping after DR1-DRB1, DR2-DRB1 and DRB5 group-specific amplifications showed that there was no DR2-DRB1 product in these cells and demonstrated the segregation of a DR103 DR51 haplotype in the family.

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