Background: Septal ventricular defect is an acyanotic heart condition that requires operation. Pulmonary artery pressure is a major determinant in the outcome of surgery Objectives: Evaluation of the usage of antihypertensive pulmonary medicines after surgical closure of septal ventricular hypertension defects. Materials: 60 patients were chosen for primary ventricular septal defect surgical repair. Instances with congenital abnormalities were eliminated rather than PDA or ASD and redo cases. These cases were divided into two groups (each of 30 patients) one with oral sildenafil and the other with no oral sildenafil. Results: The mean pulmonary artery pressure of sildenafil dropped from 66.4 ± 9.1 to 42.5 ± 3.6 mmHg and decreased to 50.2 ± 5.3 mmHg in the control group. Conclusion: Pulmonary antihypertensive medicines have an essential role in reducing pulmonary artery pressure and provide improved surgical outcomes.

No abstract

The aims of the study were to evaluate serum total cholesterol and serum C-reactive protein as a prognostic factor for survival in critical ill patients . The study population consisted of 50 patients (age range, 18-90 years; median, 55 years; men/women ratio, 2:3) in critical ill patients . Patients' serum levels of total cholesterol and Creactive protein were measured upon admission to citical care unit, three days later, and on the day discharge from ICU. Total cholesterol levels were significantly lower among the non-surviving patients (day 0,1 1 5 . 4 ± 29.66 mg/dL; day 3,113.2 ± 37.19 mg/dL; day of discharge,104.0 ±42.96 mg/dL) than surviving patients (day 0,142.5 ± 23.93 mg/dL [P = 0.001]; day 3 ,145.5 ± 28.17 mg/dL [P = 0.001]; day of discharge 147.5 ± 35.97 mg/dL [P = 0.001]). C-reactive protein levels were significantly higher among the non-survivors (day 0,136.8 18.77 mg/dL; day 3,155.1 ± 18.94 mg/dL; day of discharge178.5 ± 22.30 mg/dL) than survivors (day 0,68.85 ±19.73 mg/dL[P = 0.001]; day 3,63.08 ± 18.05 mg/dL[P = 0.001]; day of discharge,52.98 ± 14.25 mg/dL;[P = 0.001]). Serum cholesterol and C-reactive protein can be used as markers for predicting survival in critical ill patients . Low cholesterol and high C-reactive protein levels appear as a valuable tool for individual risk assessment in critical ill patient.

No abstract

Hyperglycemia is common event in critical unit including patients with or without history of diabetes . in patients with septic shock , blood glucose level easily elevated by complex of pathophysiological mechanisms , we investigate the effect of normalization of blood glucose in septic shock patients including the morbidity , the mortality, the length of icu stay and the time on mechanical ventilation We included 60 patients divided into two groups.Group1:consist of 30 patients was applied to intensive glycemic control. Group 2: consist of 30 patients was applied to conventional glycemic control. We found that strict normalization of blood glucose have favourable outcome than conventional control in morbidity but not mortality. 20 % in group 1 needed hemodialysis and 80 % of patients required hemodialysis in group 2 which is statistically highly significant. Mortality rate 60% in group 1 and 80% in group 2 which is statistically insignificant. We found that intensive glycemic control have more favourable effects on patient morbidity but have no effect on mortality The misuse of antibiotic and the co-morbidities have direct negative effect in the response to medication and the progression of the disease Hypoglycemia is noticed more in intensive study.