Results In the unpaired analyses, an inverse educational gradient in CVD risk was observed, particularly in women. This association was not replicated in the intrapair analyses of female MZ twins, but it persisted among female DZSS twins. For men, the pattern was less clear. Conclusions The attenuation of association in the intrapair analyses suggest that shared familial factors account for part of the observed association between education and CVD. The fact that it was primarily attenuated in MZ twins may point to genetic factors as an important source of confounding. However, since education was associated with CVD in the intrapair analysis of DZSS twins, there was still some evidence of effect of education. Finally, these Danish data suggest that the social inequality in CVD is larger for women than for men. Introduction Changes in meteorological parameters have been associated with stroke occurrence. The incidence of primary intracerebral haemorrhages (PICH) seems to increase in days with cold/ mild outdoor temperature. In Portugal, neurologists forward the hypothesis that the incidence of PICH increases in rainy days and not particularly low temperatures. This study aims to study the association between occurrence of PICH and weather parameters. Methods Data from ACINrpc-project, involving 78 patients suffering a first-ever-in-the-lifetime PICH over a 2-year period in the city of Porto was used. Information on daily weather parameters was obtained from the National Meteorological Office. A Poisson model was used to estimate the association between weather parameters and PICH incidence. Using a conditional logistic regression model, a case-crossover design was then used to estimate the risk of PICH following specific exposures associated with PICH incidence: low diurnal temperature range (DTR) and rainy days. For each subject, the case period was matched with 4 control periods, the same weekday in the previous 4 weeks. Results PICH incidence increases by 11.8% (95% CI 3.8 to 20.4%) for 18C drop in DTR and 3.1% (95% CI 1.1 to 5.1%) for a 1 mm/m 2 in precipitation. Following a day with a DTR<48C the OR is 2.9 (95% CI 1.4 to 5.8), increasing to 8.8 (95% CI 1.7 to 44.8) after a 48 h exposure. Following days with low DTR and rain, the OR is 3.2 (95% CI 1.3 to 8.1) and 9.5 (95% CI 1.1 to 88.9) for a precipitation>10 mm/m 2 and 40 mm/m 2 , respectively. Conclusion Precipitation by itself is not associated with PICH incidence, nevertheless has a synergistic effect in low DTR days. P1-466 EFFECTS OF OUTDOOR TEMPERATURE AND RAIN ON THE RISK OF HEMORRHAGIC STROKE

, based on linked records of the use of mental health services, hospital admissions, Medicare claims for GP and specialist services, electoral roll registration and deaths. Adjusted rate ratios (ARRs) for the number of visits to GPs by MHCs relative to non-MHCs, and for different categories of mental disorders. Results Relative to non-MHCS, the ARR of visits to GPs by MHCs was 1.622 (95% CI 1.613 to 1.631) overall, and was elevated in each separate category of mental illness. ARRs were highest for alcohol/ drug disorders, schizophrenia and affective psychoses (2.404, 1.834 and 1.798, respectively). The results were not changed by location (metropolitan, rural or remote addresses). However, the 4% of MHCs with no fixed address had a very low ARR of visits to GPs (0.058; 95% CI 0.057 to 0.060). Conclusion MHCs visit GPs substantially more often than nonMHCs, with the exception of those with no fixed address who seldom see a GP at all.