Shigruguggulu is anubhoota yoga of Banaras Hindu University using as analgesic and anti-inflammatory since long time in the Shalya Ward and OPD of the Sir Sunderlal Hospital, Banaras Hindu University. Present research work was done on 150 healthy patients. The patients were divided into three Groups. Each Group included 50 patients with age (16-60 years), height and weight distribution. The patients were posted for primary threading, herniotomy with herniorrhaphy and hemorrhoidectomy, skin grafting, sentinel tag, tubectomy and abdominal hysterectomy. Group I was pre medicated with two capsules of Shigruguggulu 500 mg (2/3 part of Shigru root bark decoction and 1/3 Shigru root bark choorna with guggulu) orally at 10 pm and 90 minute before anesthesia and inj. Glycopyrrolate 0.2 mg IM, 60 minute before anesthesia. Group II was pre medicated with two capsules of Shigruguggulu 500 mg (Shigru root bark decoction with guggulu) orally at 10 pm and 90 minute before anesthesia and inj. Glycopyrrolate 0.2 mg IM, 60 minute before anesthesia. Group III was pre medicated with tab. Diclofenac sodium 50 mg orally 10 pm and 90 minute before anesthesia and inj. Glycopyrrolate 0.2 mg IM 60 minute before anesthesia. It was observed that no alteration in Mean Blood Pressure, respiratory rate, pulse rate, temperature and liver function test etc. Post anesthetic sequel, like nausea, vomiting, headache, backache, CNS irritability was observed insignificant in all the three Groups. It means that drug has no any side effect.