Introduction:Drug-related problem (DRP) is any undesirable event experienced by the patient, which is suspected to involve drug therapy and interferes with a desired patient outcome. Most of these DRPs are avoidable with little vigilant effort. DRP admissions need high attention as DRP-related admissions on an average accounted for 8.36%, of which 50% are avoidable. The aim of the study was to identify the risk factors associated with DRPs in tertiary care hospital.Materials and Methods:One year prospective observational study was conducted in the departments of general medicine, dermatology, pediatrics, and gastroenterology of a tertiary care teaching hospital. A total of 148 cases, where a correlation between past medication history and current complaints was established, were included in the study. Exclusion criteria of the study were no correlation between past medication history and current complaints, social habits causing hospitalization, and herbal medication use history.Results and Discussion:In this study, nonadherence (50.94%) and adverse drug reaction (ADR) (38.36%) were predominant among the identified DRPs. Children and geriatrics showed the higher incidence of nonadherence to the prescribed therapy. ADRs were the DRP with the higher incidence among adults followed by nonadherence to the prescribed therapy. Lack of knowledge about the disease, its complications, and possible adverse reactions with self-medication was identified to be the high incidence risk factor. Higher incidence of DRPs was observed in patients having a past medical history of cardiovascular system and central nervous system diseases, which require long-term management.Conclusion:In this study, nonadherence to prescribed therapy was found to be the DRP causing hospitalization at a higher incidence. The most commonly involved risk factors were lack of knowledge about the disease, need of adherence to the therapy as prescribed, and outcomes of the treatment provided.

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Diabetes is emerging global burden and is defined as chronic metabolic disorder that results in elevated level of blood glucose and is due to beta cell destruction. Gestational diabetes is the type of diabetes that occurs in women during pregnancy or first recognized at the Gestational period. The prevalence of Gestational diabetes is increasing tremendously in developing countries. Approximately 2 to 14% of pregnancy is diagnosed with Gestational diabetes and 90% of all Gestational diabetes is reported from low- and middleincome countries. Of these North Africa has the highest prevalence followed by South Asia. The chance of developing type 2 diabetes is 7 times higher in women with previous history of Gestational diabetes and also it involves in increasing the risk of cardio metabolic disorders in later life. Gestational diabetes results from various complex interactions of environmental, genetic and maternal factors. Polycystic ovarian syndrome (PCOS), a major cause of infertility in women causes hormonal abnormalities and is also associated with insulin resistance. There exists a relationship between Gestational diabetes and PCOS stating that PCOS increase the risk of Gestational diabetes since insulin resistance is common factor in both. It is observed that the risk of Gestational diabetes is threefold higher n women with PCOS. Both PCOS as well as Gestational diabetes affects the quality of life of women due to many pathological changes. Life style modification is essential for management of PCOS and Gestational diabetes. Insulin therapy is recommended to treat hyperglycemic condition during pregnancy.