In animal models for screening for anticonvulsant activity, it has been scientifically established that medicinal herbs used in traditional medicine for the treatment of epilepsy possess promising anticonvulsant properties and can be a source of newer anticonvulsants. This study's objective was to evaluate the ethanolic root extract of Clitoria ternatea Linn for its preliminary phytochemical components, anticonvulsant, and anxiolytic effects. Anticonvulsant activity was evaluated against Maximum electroshock (MES) induced convulsion and pentylenetetrazole (PTZ)-induced convulsion model in rats. Using phenytoin (25 mg/kg) as a standard drug, the efficacy of the extract at oral dose levels of 200 and 400 mg/kg were evaluated in an experimental rat model. The marble bury test was used to assess the mice for anxiolytic activity, and lorazepam served as the standard drug at a dose of 0.05 mg/kg. Phytochemical screening revealed that C. ternatea extract contain carbohydrates, flavonoids, alkaloids, proteins, triterpenoids, phenols and steroids. The ethanolic extract significantly decreased the duration of tonic flexion and tonic extension in MES induced model (p<0.05). The ethanolic extract significantly increased the latency of convulsion and decreased the duration of convulsion in PTZ induced model (p<0.05). The ethanolic root extract were found to be significantly decrease the number of marbles buried in the treated groups as compared to control group, indicating anxiolytic activity. According to specific investigations, terpenes and steroids exhibited anticonvulsant effects in some experimental seizure models, including MES and PTZ. Alkaloids and triterpenes, which are phytoconstituents in ethanolic extract of Clitoria ternatea (EECT), might be the basis of its anxiolytic actions. Based on the findings of the study, Clitoria ternatea's ethanolic root extract has anticonvulsant and anxiolytic effects on animals.

The swimming endurance test, anoxic tolerance test, and basal activity by actophotometer were used to assess the antistress activity of a seven-day therapy (200 and 400 mg/kg, p.o.) of the ethanolic extract of Coriandrum sativum (EECS) aerial parts. A method for measuring the in vitro antioxidant activity of hydroxyl radicals was used. In all of the examined models, Coriandrum sativum at both doses demonstrated antistress effects. In the anoxic tolerance test, swimming endurance test, and duration of stay on the rotarod, the EECS treated rats demonstrated enhanced swimming time, duration, and anoxic tolerance time, respectively. The C. sativum's potential to scavenge free radicals, which enhanced the cognitive effect, was utilized to determine the in vitro antioxidant activity. The results demonstrated clearly that the extract's in vivo adaptogenic performance and cognitive improvement were caused by its in vitro antioxidant activity. The EECS treated animals showed increase locomotor scores in basal activity by Actophotometer. The plant secondary metabolites flavonoids, glycosides, triterpenoids, and phenolic components may be accountable for the animals' improved swimming endurance, stress tolerance, and overall performance. This study gave evidence that the ethanolic extract of Coriandrum sativum has antioxidant, anti-stress, and nootropic activity, and that utilizing them by humans as nutraceuticals is beneficial and scientific. By stress reduction in animals, the antioxidant effect provides the pharmacological basis for supporting a healthy memory.