The efficacy of eight anthelmintics against Ancylostoma caninum larvae in the skeletal muscles of mice was evaluated. Levamisole (5 × 40 mg kg), thiabendazole (5 × 400mg kg), oxfendazole (5 × 100mg kg), albendazole (5× 1OOmg kg), flubendazole (5 × 200 mg kg), benacil (5 × 200 mg kg) and phenacizole (5 × 200mg kg) showed marked larvicidal activity (98 to 99%). Sch 18099 did not show larvicidal activity even at 5×400 mg kg.

In an experimental larval infection of Ancylostoma caninum in mice, the efficacy of various anthelmintics against the larvae migrated and established in the brain is reported for the first time. Albendazole and flubendazole were the most effective drugs. Thiabendazole, benacil, phenacizole, oxfendazole and mebendazole showed significant larvicidal activity. Tetramisole, levamisole, fenbendazole, Sch 18099, pyrantel pamoate, morantel tartrate and oxantel pamoate did not show any significant activity even at relatively high dose levels.

No abstract