A multifunctional biocompatible nanovector based on magnetic nanoparticle and carboxymethyl cellulose (CMC) was developed. The nanoparticles have been characterized using TEM, SEM, DLS, FT-IR spectra, VSM, and TGA studies. We found that the synthesized carboxymethyl cellulose magnetic nanoparticles (CMC MNPs) were spherical in shape with an average size of 150 nm having low aggregation and superparamagnetic properties. We found that the folate-tagged CMC MNPs were delivered to cancer cells by a folate-receptor-mediated endocytosis mechanism. 5-FU was encapsulated as a model drug for delivering cytotoxicity, and we could demonstrate the sustained release of 5-FU. It was also observed that the FITC-labeled CMC MNPs could effectively enter cells, and the fate of nanoparticles was tracked with Lysotracker. The CMC MNPs could induce significant cell death when an alternating magnetic field was applied. These results indicate that the multifunctional CMC MNPs possess a high drug loading efficiency and high biocompatibility and with low cell cytotoxicity and can be considered to be promising candidates for CMC-based targeted drug delivery, cellular imaging, and magnetic hyperthermia (MHT).

The bio-diesel industrial waste,Pongamia pinnataseed shell was utilized as a potential adsorbent for the toxic textile dye ‘Reactive Red 2’. Preliminary information was gathered by batch mode contact time adsorption studies, which include effect of pH, contact time, dye concentration and temperature. Plausible mechanism of the on going adsorption process and thermodynamic parameters involved were obtained by carrying out kinetic measurements. To identify whether the on going process is particle diffusion or film diffusion, the treatment given by Boyd and Reichenberg was employed.

Microbial exopolysaccharides (EPSs) are highly heterogeneous polymers produced by fungi and bacteria that have garnered considerable attention and have remarkable potential in various fields, including biomedical research. The necessity of biocompatible materials to coat and stabilize nanoparticles is highly recommended for successful application of the same in biomedical regime. In our study we have coated magnetic nanoparticles (MNPs) with two bacterial EPS-mauran (MR) and gellan gum (GG). The biocompatibility of EPS coated MNPs was enhanced and we have made it multifunctional by attaching targeting moiety, folate and with encapsulation of a potent anticancerous drug, 5FU. We have conjugated an imaging moiety along with nanocomposite to study the effective uptake of nanoparticles. It was also observed that the dye labeled folate targeted nanoparticles could effectively enter into cancer cells and the fate of nanoparticles was tracked with Lysotracker. The biocompatibility of EPS coated MNPs and synergistic effect of magnetic hyperthermia and drug for enhanced antiproliferation of cancer cells was also evaluated. More than 80% of cancer cells was killed within a period of 60 min when magnetic hyperthermia (MHT) was applied along with drug loaded EPS coated MNPs, thus signifying the combined effect of drug loaded MNPs and MHT. Our results suggests that MR and GG coated MNPs exhibited excellent biocompatibility with low cell cytotoxicity, high therapeutic potential, and superparamagnetic behavior that can be employed as prospective candidates for bacterial EPS based targeted drug delivery, cancer cell imaging and for MHT for killing cancer cells within short period of time.

Positive lead time Retrial demand Finite population a b s t r a c tIn this article, we consider a continuous review perishable inventory system with a finite number of homogeneous sources of demands. The maximum storage capacity is S. The life time of each items is assumed to be exponential. The operating policy is (s, S) policy, that is, whenever the inventory level drops to s, an order for Q(= S − s) items is placed. The ordered items are received after a random time which is distributed as exponential. We assume that demands occurring during the stock-out period enter into the orbit. These orbiting demands send out signal to compete for their demand which is distributed as exponential. The joint probability distribution of the inventory level and the number of demands in the orbit are obtained in the steady state case. Various system performance measures are derived and the results are illustrated numerically.

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