«IMPORTANCE OF THE PNEUMOCOCCUS IN COMMUNITY-ACQUIRED PNEUMONIA IN TENDER-AGE INFANTS ON THE BACKGROUND OF VACCINATION» The authors of the manuscript provide data demonstrating that una pneumonia against the background of vaccination is accompanied by a change in the etiological structure. The article is a new idea and overall it is well written and structured. However, simple study design, lack of patient baseline and follow-up data limit the conclusion of withdrawal. I invite the authors to solve the following questions: 1) There are many spelling, grammatical and punctuation errors. Authors should correct mistakes and rewrite the article in a clear and understandable style. I have visited the authors with the help of a language expert on rewriting. 2) The main problem of the manuscript is poor statistical processing and statistical reporting. The authors stated: “All data were expressed as confidence intervals. Thus, it is unclear whether the etiological structure was normally distributed. Moreover, following normal scientific practice, authors should indicate specific statistical significance values ​​when comparing each test parameter. 3) The cited literature is relevant to the research and meets the requirements of the journal. But mentions of 9/19 were published over 10 years ago. I recommend reading current research on this topic. In conclusion, the work makes a good impression. On the other hand, it can be published after significant changes with reference to the comments mentioned above, including bug fixes and rewriting of the article in a clear and easily understandable style.

Determination of disruption in the oxidative metabolism system of lipids and proteins, and the presence of mitochondrial insufficiency signs are universal pathogenic mechanism that reflects the multifactorial nature of the lesion with acute rheumatic fever.