Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5–20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.Methods: Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.Results: This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.Conclusions: Hemodialysis procedure contributes to inflammation and oxidative stress.

The long-term dialysis therapy for end-stage renal disease takes a heavy toll of quality of life of the patient. Several factors such as fatigue and decreased physical capability, impaired social and mental functioning, contribute to this forlorn state. To meld maintenance dialysis treatment with a regular employment can be a serious test. A cross-sectional study of employment of patients on hemodialysis and peritoneal dialysis in a state government tertiary institute in South India was performed between June 2015 and December 2015. Patients who completed 3 months of regular dialysis were only included in the study. The number of patients on hemodialysis was 157 and on peritoneal dialysis was 69. The employment status before the initiation of dialysis was 60% (93 out of 155) and 63.7% (44 out of 69) in hemodialysis and peritoneal dialysis, respectively. After initiation, the loss of employment was observed in 44% (41 out of 93) in hemodialysis and 51.2% (26 out of 44) in peritoneal dialysis (P = 0.2604). Even though there was fall of absolute number of job holders in both the blue and white collar jobs, the proportion of jobholders in the white collar job holders improved. On univariate analysis, the factors which influenced the loss of employment were males, age between 50 and 60 years, number of comorbidities >2, illiteracy and blue collar versus white collar job before the initiation of dialysis. The majority of patients had the scores above 80 on Karnofsky performance scale and the majority belonged upper and middle classes than lower classes on modified Kuppuswamy's socioeconomic status scale; however, the loss of employment was also disproportionately high. There appeared a substantial difference in the attitude of the patients toward the employment. There was no difference between hemodialysis and peritoneal dialysis in the loss of employment of our patients.

[1] The Pliocene-Pleistocene Karewa Group sediments of the Kashmir basin, India, provide an important continental archive for past climatic reconstruction. The present study reevaluates the magnetic polarity stratigraphy and the nature of the depositional environment at a 440-m-thick section along Romushi river near Pakharpur (33°48′50″N, 74°45′54″E). Magnetic remanences are predominantly carried by Ti-rich titanomagnetite and magnetite. We identified eight normal and eight reversed-polarity magnetozones in this succession, ranging between 4.40 and 0.77 Ma. The polarity sequence includes the new identification of the Cochiti and the Mammoth and their preceding and succeeding reversed/normal as well as the Jaramillo subchrons. Anisotropy of magnetic susceptibility data suggest the existence of northeast-and northwest-flowing fluvial system before 4.18 Ma, indicating the Pir Panjal range at the southwest as the sediment source area. Following this, the valley was under the influence of fluviolacustrine environment between 4.18 and 0.77 Ma. Our results suggest relatively strong flow velocity toward the northeast during the upper Gilbert, Gauss, and lower and middle Matuyama chrons (4.18-1.07 Ma). In the upper Matuyama chron (<1.07 Ma), the prevailing paleocurrent direction in the basin changed toward the northwest with a reduced flow velocity, indicating the emergence of the ancestral Jhelum river. On the basis of the magnetic polarity chronology, the sediment accumulation rate indicates a very low value of ∼4.6 cm kyr −1 before 1.95 Ma to ∼33 cm kyr −1 between 1.95 and 1.77 Ma and 23 cm kyr −1 after 1.77 Ma. We attribute temporal changes in sedimentation rate to the interplay between climate (predominantly westerlies) and tectonics (pulsating Pir Panjal uplift).

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