The pharmacological activities of the leaf gel of Aloe vera have been extensively evaluated. Gel and latex are two basic products of aloe leaves. Latex and gel contain biologically active components. Polysaccharides contained in the leaf gel attribute most of the health benefits like anti-inflammatory, pain and fever, associated with aloe vera. In the present study, chloroform extract of A. barbadensis at various concentrations was investigated for its anti-inflammatory, antipyretic and analgesic activities in albino rats. Twenty-four albino rats were randomly divided into three groups (control, standard and experimental group). Division of groups was the same for all activities. Control and standard groups contain 4 rats in each group whereas experimental group contains 16. All the rats in three groups were treated with carrageenan to induce oedema, Brewer’s yeast to induce pyrexia and acetic acid to induce pain. The control group was treated with normal saline for all the activities. Standard group rats were treated with the reference drug diclofenac for anti-inflammatory and analgesic activities and paracetamol for antipyretic activity. Experimental group rats were given chloroform extract of A. barbadensis with 50, 100, 200 and 400mg/kg concentration. The result showed a significant inhibition (98%) in oedema at 3rd hour at the dose of 400mg/kg as compared to control group. For antipyretic activity, there was a significant reduction (66%) in pyrexia at 4th hour at the dose of 50mg/kg as compared to control group. And in analgesic model a significant reduction (64%) in the writhing at the dose of 400mg/kg as compared to control group. These results demonstrated that the chloroform extract of Aloe barbadensis miller have anti-inflammatory, antipyretic and analgesic activity and suggested its inhibitory actions on inflammation, fever and pain.

Diverse natural mechanisms against pain, inflammation, and several other infections are varied for medicinal plants. Inflammation is unique biological defense mechanism against harmful stimuli like infections, harmed cells, or irritants. M. charantia is frequently used to treat a variety of illnesses, including fever, discomfort, and inflammation. The purpose of the current study is to identify the anti-inflammatory, antipyretic, and analgesic properties of ethanolic extract of M. charantia. 30 rats were divided into three groups (control, standard and experimental group). Control and standard group contain 5 rats in each group whereas experimental group contained 20 rats. All rats in three groups were treated with carrageenan for induction of oedema, yeast to induce pyrexia and acetic acid to induce pain. Control group rats were treated with normal saline for all the activities. Standard group rats were treated with diclofenac for anti-inflammatory and analgesic activities and paracetamol for antipyretic activity. The fruit extract was injected into abdominal muscles and intraperitoneal tissues.Carrageenan, an anti-inflammatory substance, was used to assess its ability to reduce spell edema, acetic acid was used to study its ability to cause writhing and yeast, was used to demonstrate its ability to pyrexia. The maximal percentage of fruit extract inhibition in anti-inflammatory action was 31.25%. The maximal percentage of fruit extract inhibition against fever was 83.58%. Maximum percentage of inhibition against stomach pain during analgesic action was 31%. Significant findings in anti-inflammatory, antipyretic and analgesic actions were demonstrated at doses of 200 mg/kg, 50 mg/kg, and 100 mg/kg, respectively, when compared to controls. Our research demonstrates and validates the traditional medical usage of M. charantia. It was concluded that ethanolic fruit extract of M. charantia may decrease inflammation, pyrexia and writhing in albino rats effectively.

Medicinal plants are effective natural anti-inflammatory, anti-pyretic, and anti-analgesic agents. Inflammation is a complicated biological defense reaction of vascular tissues to potentially damaging stimuli such as bacteria, damaged cells, or irritants. The current study aimed to establish the anti-inflammatory, antipyretic, and analgesic properties of E. globulus essential oil. In this research, 36 albino rats weighing 140-170g on average were employed. 36 rats were divided into three groups (control, standard and experimental group). Control and standard group consisted of 6 rats in each group whereas experimental group consisted of 24 rats. All rats in three groups were treated with carrageenan for induction of oedema for anti-inflammatory, brewer’s yeast to induce pyrexia to check anti-pyretic activity and acetic acid to induce pain for analgesic activity. Control group rats were treated with normal saline for all 100u µl three activities. Standard group rats were treated with diclofenac for antiinflammatory and analgesic activities and paracetamol for antipyretic activity. The essential oils were injected into abdominal muscles and intraperitoneal tissues. The maximum percentage of inhibition of leaves oil in antiinflammatory action was 54.01%. The maximum percentage of suppression of fever by essential leaves oil was 75.44% in antipyretic efficacy. The highest percentage inhibition against pain in analgesic action was 25%. Significant anti-inflammatory, antipyretic, and analgesic effects were demonstrated at 50µl/L, 100µl/L, and 12.5µl/L doses, respectively, when compared to control group. From overall result, it was concluded that injection of E. globules leaves oil in abdominal and intraperitoneal muscle may possess significant anti-inflammatory, antipyretic and analgesic activities. Our study scientifically supports traditional use of E. globulus as a medicine.

An evergreen tropical tree known as neem (Azadirachta indica) has long been used in traditional medicine to various conditions, including fever, pain and inflammation. The prospective research aims to examine the analgesic, antipyretic and anti-inflammatory properties of the chloroform extract of A. indica. For this investigation, 108 albino rats weighing 160 to 200g each were employed. Carrageenan was used to induce paw edema to test the anti-inflammatory activity. Yeast was used to induce pyrexia to test the anti-pyretic activity. Finally, acetic acid induced abdominal writhing in rats to test the analgesic action. The chloroform extract was injected into the abdominal muscle and intraperitoneal tissue. The largest percentage of anti-inflammatory action that chloroform leaf extract could suppress was 53%. The maximal percentage inhibition of leaf extract against fever in terms of antipyretic efficacy was 90%. The highest percentage of inhibition against pain during analgesic activity was 56%. When compared to the common medications diclofenac and paracetamol substantial outcomes were seen in the anti-inflammatory, antipyretic and analgesic actions at 400 mg/kg, respectively. Fever, pain and inflammation all decreased significantly (p≤ 0.05). As a result, chloroform leaf extract from A. indica can be utilized as a potent medication to treat fever, pain (discomfort) and inflammation.