Much attention has been drawn to the recent discoveries by the Advanced Laser Interferometer Gravitational-Wave Observatory (LIGO) of merging intermediate mass black holes. Of particular interest is the possibility that the merger events detected could be evidence of dark matter in the form of primordial black holes (PBHs). It has been argued that the presence of many black holes would effect the thermal and ionization history of the universe via their accretion of matter which would have strong signatures in the Cosmic Microwave Background's (CMB) power spectra evident in the damping of anisotropies and change in low-l polarization power. In general the accretion is quite sensitive to the specific physics involved and the conditions of the early universe. In this work, we take a minimal approach and find constraints on PBHs not including the model dependent effects of nonlinear structure of formation or transition between different accretion models which would work to increase the effect. In addition, we include the relative velocity between dark matter and baryonic matter including the effects of supersonic streaming at high redshift which work to significantly reduce the constraining power. We also examine the constraints on more astrophysically-motivated extended black hole mass functions and discuss how mergers might effect this distribution. We find constraints on PBHs in the range ≈ 30M , finding that they could not compose more than 10% of the total dark matter content.

Fatal outcomes are possible even with colchicine doses less than 0.5 mg/kg. Physicians caring for colchicine-poisoned patients must be prepared for the possibility of acute cardiovascular collapse and ventricular dysrhythmias regardless of the reported dose of colchicine.

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We report the case of a pregnant woman with chronic lead toxicity and a blood lead of 57 microg/dL (2.7 micromol/L) who gave birth to a healthy-appearing neonate with a cord blood lead of 126 microg/dL (6.08 micromol/L). The mother was prescribed a single course of oral succimer late in the third trimester of pregnancy, without any appreciable change in her blood lead. The neonate was initially treated with intramuscular dimercaprol and intravenous edetate calcium disodium. After 3 days, the neonate was then switched to oral 2,3-dimercaptosuccinic acid because the blood lead had declined. The child received two 19-day courses of 2,3-dimercaptosuccinic acid and had a blood lead level of 21.5 microg/dL (1.04 micromol/L) at 5 months of age. Despite extensive investigation, the precise source of the mother's lead toxicity remained undetermined.

We present the second data release of the COSMOS Lyman-Alpha Mapping And Tomography Observations (CLAMATO) Survey conducted with the LRIS spectrograph on the Keck-I telescope. This project used Lyα forest absorption in the spectra of faint star forming galaxies and quasars at z ∼ 2 − 3 to trace neutral hydrogen in the intergalactic medium. In particular, we use 377 objects over a footprint of ∼ 0.2 deg 2 to reconstruct the absorption field at 2.05 < z < 2.55. We apply a Wiener filtering technique to the observed data to reconstruct three dimensional maps of the field over a volume of 4.1 × 10 5 h −3 Mpc 3 . In addition to the filtered flux maps, for the first time we infer the underlying dark matter field through a forward modelling framework from a joint likelihood of galaxy and Lyα forest data, finding clear examples of cosmic voids, filaments, and nodes. This work constitutes the highest redshift identification of the large scale cosmic web. In addition to traditional figures, we present a number of interactive three dimensional models to allow exploration of the data and qualitative comparisons to known galaxy surveys. We find that our inferred over-densities are consistent with those found from galaxy fields. We will make all our reduced spectra, extracted Lyman-α forest pixel data, and reconstructed tomographic maps available publicly upon publication.