The main purpose of this study is to examine the impacts of the distance to city center (CIC) and distance to economic activity center (EAC) on urban growth. Land use/cover (LUC) map of 2005 and 2009 are used to analyze the variables. The variables were tested using Multi-Layer Perceptron (MLP) Neural Network in IDRISI®Selva. The result of MLP process shows that the distance to CIC and the distance to EAC contributed to the urban growth in Banda Aceh between 2005 to 2009. The distance to CIC more influential than the distance to EAC on urban growth.