Previous research indicates the prevalence of burnout among nurses and educators. Factors of burnout need to be identified to help prevent its adverse outcomes on work and well-being, especially among women from the Middle East who are underrepresented in burnout studies. Drawing from an online survey among 299 female nurse educators in Saudi Arabia, this study aims to examine personal and work characteristics, task demands, social support and activities outside work as determinants of burnout, which was measured using the Maslach Burnout Inventory (MBI). This crosssectional study made use of descriptive and bivariate statistics, and hierarchal regression to analyze the data. Findings indicate moderate burnout among the respondents. Younger, Saudi nationals, with only a master's degree and a rank below assistant professor, more years in service and no administrative position demonstrate higher levels of MBI. Work pressure and social support positively predicted MBI, while house of sleep per day was inversely related to MBI. This study provides evidence to inform policies, programs, and other initiatives of nursing education institutions to address faculty members with or at risk for burnout.