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Objective: Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), chronic inflammatory diseases, demonstrate an increased incidence of cardiovascular manifestations and subclinical atherosclerotic disease. Salusin-α is a novel bioactive peptide that suppresses the formation of macrophage foam cells, and its serum level is significantly lower in patients with angiographically proven coronary artery disease. The aims of the study were to assess serum salusin-α level and its potential association with the predictors of atherosclerosis in SLE and SSc. Material and Methods:The study included 20 SLE and 22 SSc patients and 23 healthy controls (HC). All of the participants were female. Tumour necrosis factor-α (TNF-α), IL-6 and salusin-α levels, homeostasis model assessment for insulin resistance (HOMA-IR) index and common carotid intima-media thickness (IMT) were determined.Results: Salusin-α levels were lower and the IMTs were higher in the SLE and SSc groups than in the HC group. The salusin-α level was correlated with neither the disease activity scores nor cytokine levels and IMT in the SLE and SSc groups, although it was correlated with triglyceride level in the SLE group (r=-0.564, p=0.012), and with HOMA-IR index in the HC group (r=0.485, p=0.019). Conclusion:The present preliminary study may support the idea that SSc leads to subclinical atherosclerosis, as in SLE. Moreover, it can be concluded that the decreased salusin-α levels in SLE and SSc may contribute to subclinical atherosclerosis. However, further studies with larger sample size are needed to demonstrate this contribution in SLE and SSc.

Acil servise üst gastrointestinal kanama ile başvuran hastalarda bazı skorlama istemleri ve ortalama platelet hacminin mortalite öngörüsünde değeri Results:The most frequently seen endoscopic pathology was erosive gastritis (30 patient, 22.4%). The mortality of the patients with high MPV value 40%. The cut-off value of Rockall score in mortality prediction was 6, the area under curve value was 0.888; the cut-off value of Blacthford score was 11, the area under curve was 0.818. Conclusion:The first evaluation of the patients admitted to the emergency department with upper gastrointestinal bleeding should be done by Rockall and Blatchford score and the patients with high risk should be followed closely.

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