Background. Lifestyle includes routine and daily living activities affecting an individual’s health. The present study aimed at evaluating the health-promoting lifestyle profile (HPLP) of medical sciences students of Kermanshah, Iran. Methods. In this cross-sectional study, 343 medical sciences students were enrolled by the stratified random sampling method. The data collection tools were demographic information form and the HPLP-II questionnaire. Data were analyzed using descriptive and analytical statistics. Results. The mean overall HPLP-II score of the subjects was 2.25 ± 0.44 out of 4. Of the six HPLP-II dimensions, the highest and lowest scores belonged to interpersonal relations and physical activity, respectively. The mean overall HPLP-II score was statistically different in terms of gender, marital status, smoking habits, and economic status ( P ≤ 0.05 ). Conclusion. HPLP-II level was moderate in most of the students, and health-promoting behaviors, in the physical activity dimension, were in a low state. The results emphasized the need for interventions to improve students' lifestyles.