In recent years, the field of probiotics and postbiotics has attracted the attention of many. On the one hand, probiotics when administered in adequate amounts, confer a range of a health benefits on the host but concerns have been reported about the administration of live microorganism and its associated risks. On the other hand, postbiotics with desirable traits as inactivated microbial cells or cell fractions, could non-cytotoxically benefit the consumer when ingested in sufficient amounts. In this document authors have attempted to question and answer the protentional of postbiotic as safe alternatives to live probiotic microbes in functional foods, nutraceuticals, and pharmaceutical products.