Background: Prostate cancer (PC) is one of the most common cancers worldwide. Some studies support that chronic inflammation of prostate tissue plays a role in the development of PC. A variety of growth factors and cytokines may lead to proinflammatory processes within the prostate. Objectives: The aim of the present study was to investigate the effects of eight weeks of regular resistance training and prostatic massage on proinflammatory markers) CRP, IL-6, TNF-α, and IL-10 and serum prostate-specific antigen (PSA levels in males with PC). Patients and Methods: Forty-five patients with PC were selected for this study. They were randomized into either the resistance training intervention group (n = 15), the massage intervention group (n = 15), or the control group (n = 15). Resistance-training patients participated in resistance training for eight weeks, and massage was performed for six weeks on the massage group. Repeated measures analysis of variance (ANOVA) was used to analyze the data (P ≤ 0.05). Results: In the resistance training group, IL-10 levels significantly increased after four (P = 0.055) and eight weeks (P = 0.000). Four and eight weeks of resistance training showed a significant reduction in PSA, CRP, IL-6, and TNF-α levels (P < 0.05). Patients of massage intervention showed an increase in IL-10 after four (P = 0.045) and six weeks (P = 0.005). In addition, four and six weeks of massage intervention showed a significant reduction in PSA, CRP, IL-6, and TNF-α levels (P < 0.05). Conclusions: Regular resistance training and prostatic massage can improve proinflammatory markers and PSA levels in men with PC.