Overweight and obesity are received a great concern and becoming a high priority globally. Obesity is associated with diversity of health problem as well as decline in quality of life. This study was designed to estimate the prevalence of obesity; the association between body mass index, waist-to-hip ratio and quality of life. The design used in this study was descriptive correlational design. Study subjects were convenience samples of 310 adult female recruited from female colleges in Wadi Addawasir. The data was collected using self-administered questionnaire that consisted of socio-demographic data, participants' weight perception, World Health Organization Quality of Life-Brief (WHOQOL-Brief) and anthropometric measurements included weight, height, waist circumference, hip circumference. The main findings of this study indicated that the prevalence of general obesity according to BMI was 29.7%, and abdominal obesity according to WC, and WHR were 34.2% and 35.5%, respectively. A statistically significant difference between participants' weight perception and the existing BMI, X 2 = 50.52, P = 0.00, indicated participants misperception of their weight. The mean total score of WHOQOL-Brief scale was (70.01±11.31) and social relationships domain was the highest score, the mean = 73.02 ± 17.10, while lowest score was psychological domain, the mean = 64.76 ± 13.73. Moreover, 32.3% of subjects good quality of life, while only 3.9% had poor quality of life. A significant negative correlation was revealed between BMI, WC, WHR and total score of quality of life, p = -.012,.033,.012 respectively. Moreover, the participants with increased BMI had decreased quality of life compared to those of normal BMI F = 3.209, P =.023. Conclusion: General and abdominal obesity were highly prevalent among adult Saudi females as measured by BMI, WHR. Misperception of weight was revealed and minority of subjects had good quality of life. Obesity was associated with significant decrease in quality of life. Recommendation: Effective health education strategies are required to help in increase females' awareness and perception of their weight, thus affecting their decisions and behaviors to minimize obesity and its negative influences on their health and consequently their quality of life.
