Though tuberculosis (TB) is commonly seen, peripheral gangrene as a manifestation of TB is not common. Spinal TB presents with backache, paraparesis, or quadriparesis with or without bladder and bowel involvement. It may cause spinal deformities. However, peripheral gangrene is not a common manifestation of spinal TB. Here, we present the case of spinal TB, with peripheral gangrene in a 30-year-old female. There was blackening and shrinkage of the left third toe, with superficial tenderness, darkening, and loss of sensation over the left fourth and fifth toes. Tuberculin test and Mantoux test were positive. The magnetic resonance imaging findings were suggestive of Pott's spine. Arterial Doppler of the affected lower limb revealed sluggish flow, as suggested by the biphasic waveform. The patient was started on antituberculous treatment. Although the neurological symptoms improved with antituberculous treatment, the peripheral gangrene resolved only partially and required amputation.

Introduction: Aspirin is widely used for the treatment of stroke. Therefore aspirin resistance can lead to a significant increase in the burden of stroke. Platelet aggregation studies can evaluate platelet function, and this may help to detect anti-platelet resistance. Methods: This is a hospital-based study of the antiplatelet effect of aspirin in ischemic stroke, during a duration of one year. All first-time ischemic stroke patients >18 years of age were included. Platelet aggregometry test was done by LTA (Light transmission optical aggregometer), after starting the patients on oral aspirin. Results: A total of 113 ischemic stroke patients were included for the antiplatelet effect of the aspirin study.  Aspirin resistance was found in 18.58% of patients. Patients with aspirin resistance had higher mortality, and less improvement on follow-up, as compared to aspirin-sensitive patients. They had more incidence of smoking, alcohol abuse, diabetes mellitus, and dyslipidemia, as compared to the aspirin-sensitive group. The results reveal that there is a non-statistically significant trend in both mortality and prognosis between the two study groups compared: aspirin-resistant versus aspirin-sensitive patients. Conclusion: Aspirin resistance can lead to loss of functional improvement and more mortality than aspirin-sensitive patients. However, further study for drug interactions, adequate risk factor control, the genetic profile of the population is needed, to come to a definite conclusion.