No abstract

No abstract

Alzheimer’s is one of the fast-growing diseases among people worldwide leading to brain atrophy. Neuroimaging reveals extensive information about the brain’s anatomy and enables the identification of diagnostic features. Artificial intelligence (AI) in neuroimaging has the potential to significantly enhance the treatment process for Alzheimer’s disease (AD). The objective of this study is two-fold: (1) to compare existing Machine Learning (ML) algorithms for the classification of AD. (2) To propose an effective ensemble-based model for the same and to perform its comparative analysis. In this study, data from the Alzheimer’s Diseases Neuroimaging Initiative (ADNI), an online repository, is utilized for experimentation consisting of 2125 neuroimages of Alzheimer’s disease (n = 975), mild cognitive impairment (n = 538) and cognitive normal (n = 612). For classification, the framework incorporates a Decision Tree (DT), Random Forest (RF), Naïve Bayes (NB), and K-Nearest Neighbor (K-NN) followed by some variations of Support Vector Machine (SVM), such as SVM (RBF kernel), SVM (Polynomial Kernel), and SVM (Sigmoid kernel), as well as Gradient Boost (GB), Extreme Gradient Boosting (XGB) and Multi-layer Perceptron Neural Network (MLP-NN). Afterwards, an Ensemble Based Generic Kernel is presented where Master-Slave architecture is combined to attain better performance. The proposed model is an ensemble of Extreme Gradient Boosting, Decision Tree and SVM_Polynomial kernel (XGB + DT + SVM). At last, the proposed method is evaluated using cross-validation using statistical techniques along with other ML models. The presented ensemble model (XGB + DT + SVM) outperformed existing state-of-the-art algorithms with an accuracy of 89.77%. The efficiency of all the models was optimized using Grid-based tuning, and the results obtained after such process showed significant improvement. XGB + DT + SVM with optimized parameters outperformed all other models with an efficiency of 95.75%. The implication of the proposed ensemble-based learning approach clearly shows the best results compared to other ML models. This experimental comparative analysis improved understanding of the above-defined methods and enhanced their scope and significance in the early detection of Alzheimer’s disease.

Alzheimer's dementia (AD) affects memory, language, and cognition which worsens over time. It is critical to develop a reliable early detection method before permanent brain atrophy and cognitive impairment. This study uses clinical transcripts, a text-based adaptation of the original audio recordings of Alzheimer's patients. This audio transcript data is taken from DementiaBank which is the largest public dataset of AD transcripts. The study aims to show how transfer learning-based models and swarm intelligence optimization techniques can be used to predict Alzheimer's disease. To enhance the prediction performance for Alzheimer's disease, a hybrid swarm intelligence linguistic feature selection (HSI-LFS) approach is proposed that extracts a combined feature set using Particle Swarm Optimization (PSO), Dragonfly Optimization (DO), and Grey Wolf Optimization (GWO) algorithms. In addition, a transfer learning-based model called HSI-LFS-BERT, a combination of the HSI-LFS feature selection method and Bidirectional Encoder Representations from Transformer (BERT) algorithm is proposed. The proposed model is compared using two feature sets: first set consists of the initial feature set and the second set contains hybrid feature set that has been extracted using the suggested HSI-LFS method. The BERT embedding with HSI-LFS outperformed the conventional feature set providing the most accurate modeling parameters while reducing the computations by 27.19%. The proposed HSI-LFS-BERT model excelled state-of-the-art models achieving 98.24% accuracy, 91.56% precision, and 98.78% recall.

Date of publication xxxx 00, 0000, date of current version xxxx 00, 0000.