Rapid transmission of COVID-19 disease and the fatal effects of the disease lead researchers to use various way to find potential anti-COVID-19 compounds, including using modern approaches. Molecular docking is one of the methods that can be used to analyse antiviral compounds and its molecular target from Indonesian herbs that are believed to have properties as anti-COVID-19. This study aims to analyse antiviral compounds from 5 herbs that have the potential as inhibitors of PLpro and 3CLpro, which both are a non-structural protein in SARS-CoV-2 by molecular docking approach using PLANTS. Remdesivir triphosphate, the active metabolite of remdesivir, was used as the comparison compound in studies. The results showed docking scores obtained from interactions between natural ligands, remdesivir trifospat, curcumin, demetoksikurkumin, bisdemetoksikurkumin, luteolin, apigenin, kuersetin, kaempferol, formononrtin-7-O-glucoronide, androgafolide, and neoandrogafolide with PLpro are as follows -111,441, -103,827, -103,609, -102,363, -100,27,-79,6655, -78.6901, -80.9337, -79.4686, -82.1124, -79.1789, and -97.2452.Combination between quercetin, neoandrographolide, bisdemethoxycurcumin, demetoxycurcumin, and curcumin showed a synergy effect by reduce its docking score. Meanwhile its interaction with the protein 3CLpro showed docking score for those compounds as follows 64.0074, -86.1811, -81.428, -87.1625, -78.2899, -73.4345,-70,3368, -71.5539, -68.4321, -72.0154, -75.9777 and -93.7746.Combination between andrographolide, neoandrographolide, bisdemethoxycurcumin, demetoxycurcumin and curcumin, also shows synegy effect in 3CLpro allow them to reduce the docking score.This study concludes that curcumin was known as the most potent compound that act as a PLpro inhibitor based on a docking score of -103,609, while in 3CLpro all the compound have a potential to inhibit 3CLpro with demethosxycurcumin and  neoandrogafolide as the most potent compound with a docking score -87,126 and -93.7746.

Desa Senggigi merupakan salah satu daerah yang kekurangan pasokan air bersih, khususnya di Dusun Senggigi RT 04.Kondisi ini sangat memprihatinkan, sebab ketika musim kemarau tiba sangat sulit untuk memperoleh air bersih.Adapun air PDAM maupun air sungai sangatlah keruh sehingga tidak layak untuk digunakan.Oleh karena itu,dibutuhkan sebuah solusi terkait pengelolaan air keruh menjadi air bersih, yaitu PERAK (Peranti Pemurni Air Keruh).Tujuan dibuatkan program ini adalah terciptanya suatu alat pemurni air keruh (PERAK),terbentuk masyarakat yang terampil dalam mengelola air keruh menjadi air bersih, dan terbentuknya KelompokSwadaya Masyarakat di Dusun Senggigi. Metode yang digunakan dalam program ini adalah sosialisasi dan pelatihan pembuatan PERAK. Adapun hasil yang didapatkan pada pelaksanaan program ini adalah PERAK telah dapat menghasilkan air bersih yang dapat digunakan untuk keperluan kehidupan sehari-hari.Selain itu warga Dusun Seggigi juga telah mampu membuat PERAK dan telah dibentuknya Kelompok Swadaya Masyarakat yang bertugas memonitoring pelaksanaan program sehingga tercipta kemandirian dalam pelaksanaan program tersebut.Dengan demikian PERAK telah berhasil menjadi solusi bagi permasalahan kekurangan air bersih bagi Dusun Senggigi.Kata kunci: Air Bersih; Air Keruh; Pemurni Air; PERAK; Senggigi.AbstractSenggigi Village is one of the areas that lack of clean water supply, especially in Dusun Senggigi RT 04. This condition is very concerning, because when the dry season comes, it is very difficult to obtain clean water. The PDAM water or river water is very muddy so it is not feasible to use. Therefore, it takes a solution related to the management of turbid water into clean water, which is PERAK (Refrigerant Water Purifier). The purpose of this PERAK program is to create a turbid water purification tool (PERAK), to form a skilled community in managing turbid water into clean water, and forming Self-Help Groups in Senggigi Village. The methods used in this program are socialization and training on making PERAK. As for the results obtained in the implementation of this program is PERAK has been able to produce clean water that can be used for the purposes of everyday life. In addition, residents of Dusun Senggigi has also been able to make PERAK and has formed a Self-Help Group which is tasked to monitor the implementation of the program so as to create independence in the implementation of the program. Thus PERAK has successfully become the solution for the problem of water shortage for Dusun Senggigi.Keywords: Clean Wate; Cloudy Water; Water Purifier; PERAK; Senggigi.

Corona Virus Disease 2019 (COVID-19) is a new strain of coronavirus called SARS-CoV-2, which was identified in Wuhan, China, in December 2019. The rapid transmission of COVID-19 from human to human forced researchers to find a potent drug by setting aside the time-consuming traditional method in drug development. The molecular docking approach is one a reliable method to screening compound from chemical drug or by finding a compound from Indonesian herbal plants. The present study aimed to assess the potency of compounds from five medicinal plants as potential inhibitors of PLpro and 3CLpro from SARS-CoV-2 using molecular study. The molecular docking was performed using Protein-Ligand Ant System (PLANTS) to analyze the potential compounds by the docking score. Remdesivir triphosphate was used as a standard for the comparison of the test compounds. The docking score obtained from the docking of PLpro with native ligand, remdesivir triphosphate, curcumin, demethoxycurcumin, bisdemethoxycurcumin, luteolin, apigenin, quercetin, kaempferol, formononetin-7-O-glucuronide, andrographolide, and neoandrographolide were -111.441, -103.827, -103.609, -102.363, -100.27, -79.6655, -78.6901, -80.9337, -79.4686, -82.1124, -79.1789, and -97.2452, respectively. Meanwhile, docking score with 3CLpro for the same ligand were -64.0074, -86.1811, -81.428, -87.1625, -78.2899, -73.4345, -70.3368, -71.5539, -68.4321, -72.0154, -75.9777, and -93.7746. The docking score data suggest that curcumin was the most potential as a PLpro inhibitor, while neoandrographolide was the best as a 3CLpro inhibitor.