Abstract. According to estimates by oncologists, if early tumor diagnosis and treatment in a timely manner can be achieved in the millimeter level or below, the cure rate of cancer will be able to increase to 80%-90%. With the rapid development and maturity of nano technology and scientific theory, Up-conversion nanoparticles (UCNPs) have become a tumor nanoplatform which can be used for early diagnosis and treatment.The review summarizes the progress of Up-conversion nanoparticles in detection and treatment of tumor in some research.

Abstract. In this article, designed and preparated rare earth luminescence nanoparticle through different core-shell and doping ratio, improving synthetic conditions, it has uniform size and good crystallinity. Modified nanoparticles with DTT, surface of the nanoparticles with sulphur and combine with oral cancer cell antibodies, under 980 nm infrared laser excitation, through infrared spectrum detected carcinoma antigen in serum, So as to achieve detection diagnosis to patients with oral drench carcinoma.