Crigler-Najjar syndrome is an inborn error of metabolism caused by a point mutation in one of the five exons of UGT1A1 gene, the product of which is responsible for elimination of bilirubin via bile. A number of hyperbilirubinemia disorders similar to Crigler-Najjar syndrome are reported, but they differ in their level of unconjugated bilirubin and responses to the treatment. Here we report a 14-year-old male patient admitted to hospital with the complaint of vomiting and frequent tonsillitis. Further examination revealed that he was jaundiced since birth and had a family history of similar disorder. This report is about an extremely rare case of Crigler-Najjar syndrome type II and also management of the condition to provide the patient with a healthy lifestyle.

Objectives The main objective of the study is to find the frequency of risk factors of coronary heart diseases in patients with acute coronary syndrome and its comparison in male and female. Material and methods This cross-sectional study was conducted in Services Institute of medical sciences during June 2021 to June 2022. The data was collected with the permission of ethical committee of hospital. Results The data was collected from 100 male and female patients. The mean age was 45.67 ± 2.89 years for males and 49.89 ± 5.67 years for females. The major risk factors for diseases is hypertension, hyperlipidemia, smoking and diabetes. According to data all the patients must contain one of these major risk factors and many of the patients had more then one risk factors. Conclusion It is concluded that all the patients must have one of the major risk factors as a cause of diseases. Women with acute coronary syndrome, as compared to men, have more prevalence of diabetes and hypertension, and less prevalence of smoking.

Introduction: Cardiovascular disease (CVD) is a group of diseases that include both the heart and blood vessels, thereby including coronary heart disease (CHD) and coronary artery disease (CAD), and acute coronary syndrome (ACS) among several other conditions. Objectives: The main objective of the study is to find the frequency of risk factors of coronary heart diseases in patients with acute coronary syndrome and its comparison in male and female. Material and methods: This cross-sectional study was conducted in Services Institute of medical sciences during June 2021 to June 2022. The data was collected with the permission of ethical committee of hospital. Results: The data was collected from 100 male and female patients. The mean age was 45.67±2.89 years for males and 49.89±5.67 years for females. The major risk factors for diseases is hypertension, hyperlipidemia, smoking and diabetes. According to data all the patients must contain one of these major risk factors and many of the patients had more then one risk factors. Conclusion: It is concluded that all the patients must have one of the major risk factors as a cause of diseases. Women with acute coronary syndrome, as compared to men, have more prevalence of diabetes and hypertension, and less prevalence of smoking.

Introduction: Cardiovascular disease (CVD) is a group of diseases that include both the heart and blood vessels, thereby including coronary heart disease (CHD) and coronary artery disease (CAD), and acute coronary syndrome (ACS) among several other conditions.Objectives: The main objective of the study is to nd the frequency of risk factors of coronary heart diseases in patients with acute coronary syndrome and its comparison in male and female.Material and methods: This cross-sectional study was conducted in Services Institute of medical sciences during June 2021 to June 2022. The data was collected with the permission of ethical committee of hospital.Results: The data was collected from 100 male and female patients. The mean age was 45.67±2.89 years for males and 49.89±5.67 years for females. The major risk factors for diseases is hypertension, hyperlipidemia, smoking and diabetes. According to data all the patients must contain one of these major risk factors and many of the patients had more then one risk factors. Conclusion:It is concluded that all the patients must have one of the major risk factors as a cause of diseases. Women with acute coronary syndrome, as compared to men, have more prevalence of diabetes and hypertension, and less prevalence of smoking.