Magnetic anomalies in the south-western part of the Tisia Mega Unit were drilled in different geological situations: the Helesfa serpentinite body is surrounded by a Variscan granite, while the host rocks of the Gyód serpentinite body are paragneiss and amphibolite. Nevertheless, these anomalies are on opposite sides of the Mecsekalja Shear Zone, which developed during the Variscan Orogeny. Olivine, enstatite and spinel occur as relicts in the Gyód serpentinite, while the primary ultramafic rock of the Helesfa serpentinite is totally serpentinized. Based on the major-element whole-rock geochemical data, the protolith of the two serpentinites was mainly harzburgite. Based on the similar petrography, textures, mineral composition, major-element geochemistry, as well as metamorphic and structural evolution, a close genetic relationship between the Gyód and Helesfa serpentinite bodies can be supposed. Serpentinite with pseudomorphous lizardite and chrysotile textures possibly formed during the ocean-floor metamorphism. Afterwards, an antigorite ± talc assemblage developed from the pseudomorphous serpentine texture, which is sheared and mylonitized, supposedly due to subduction. Serpentinites with similar composition and evolution are widespread in the Bohemian Massif (especially in the Polish Central-Sudetic ophiolites).Keywords: serpentinite, harzburgite, websterite, Alpine-type ophiolite, Tisia, Variscides Received: 5 March, 2016; accepted: 30 September, 2016; handling editor: E. Jelínek magnetic, aeromagnetic and aero-gamma surveys, small local anomalies were recorded, which were drilled by exploration boreholes in some cases. In this way, the Gyód serpentinite (GS) and Helesfa serpentinite (HS) bodies were recognized in the crystalline basement of SW Tisia Mega Unit (Fülöp 1994). During geological exploration, a third, Ófalu serpentinite body (OS) was identified (Ghoneim and Ravasz-Baranyai 1969).The early petrographic and geochemical analyses (Ghoneim and Ravasz-Baranyai 1969;Erdélyi 1974;Szederkényi 1974Szederkényi , 1976bSzederkényi , 1977Szederkényi and Grasselly 1977; Ghoneim 1978;Jantsky 1979;Ghoneim and Szederkényi 1979;Svingor and Kovách 1981;Balla 1981Balla , 1983Balla , 1985Papp 1989) led to different opinions regarding the protoliths, metamorphic evolution and genesis of the two serpentinite bodies. Petrographic, mineralogical and geochemical comparison of the Gyód and Helesfa serpentinites, based on the available drill cores, is presented in this work. A detailed evaluation of the likely protoliths, metamorphic evolution as well as deformation history of both bodies may serve as a firm basis to delineate a uniform evolution scheme for the study area. In the future, this approach would provide data for comparisons with other serpentinite bodies in the vicinity and thus the Tisia Mega Unit's evolution.