Acetic acid production increased with the use of a flow system due to steady-state long-term operation versus batch cycling.

The driving force of homo-and heterochiral complex formation in mixtures of chiral compounds is, probably, the effort of the system to separate the most symmetric associates from the less symmetric ones. A possible way to achieve separation of these associates is distribution between two phases. Therefore, during the separation of (a certain part) diastereoisomers similar trends can be observed as in the course of the distribution of enantiomeric mixtures between two phases, although in the first case a third chiral compound (namely the resolving agent) is present. Of course in this case the pursuit of symmetry is not so obvious as in case of enantiomeric mixtures. It should be noted that the outcome may thus be modified by the intervention of kinetic control. One can conclude that the structure of chiral compounds encodes the result of the (optical) resolution.Scheme 3 The effect of the eutectic composition of racemic compound and resolving agent on the eutectic composition of diastereoisomers obtained (see also Scheme 2).Scheme 4 Separation from the melt.

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