For decades the results of elective lymph node dissection (ELND) are differently discussed, so that it is not definitely recommended at present the less so since the morbidity of this operation can't be neglected. Since the beginning of 1995 we practice a gamma-probe guided sentinel lymphonodectomy (SLNE) on patients with melanoma from a Breslow tumor thickness of 1 mm upward, after injecting a colloidal 99m-Tc labelled tin (II) - sulfide solution around the tumor or the scar, if the tumor has been excided before. By this method, that allows a selection of patients who according clinically to a stage I or II (UICC) but even histopathologically to a stage III and who are profiting of a removal of the regional lymph nodes, the sentinel node can be exactly localised, tissue-sparing removed at minimal complication rates and the completeness of the removal can be verified by measurements of the radioactivity. When finding metastases in the histopathological examination of the node a dissection of the whole region follows.
Die Behandlung der diffusen (progressiven) SkierodermieDie diffuse (progressive) Sklerodermie ist eine seltene und von den Pseudoskierodermien nicht immer leicht abgrenzbare Erkrankung unbekannter Ursache. Aus biochemischen Analysen ist lediglich bekannt, daß die Kollagensynthese gesteigert und die Quervernetzung des Kollagens verändert ist (12). Verbindliche therapeutische Richtlinien aus klinisch-pharmakologischen Studien liegen nicht vor, zumal Kriterien für objektive und kurzfristige Verlaufskontrollen fehlen. Im nachfolgenden sollen kritisch die Behandlungsmaßnahmen besprochen werden, die in letzter Zeit im Vordergrund des Interesses stehen.
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