Plants and plant derived products have been a source of alternate therapy for ages. This is because of availability and effectiveness in managing a wide range of illnesses. This study was carried out to assess the effects of a formulated herbal mixture made from Sorghum bicolor L., Curcuma longa L, Bridelia ferruginea B. and honey (STBH) on weight, biochemical parameters, hematological profile and histological effect on key organs of apparently healthy Wistar rats. The plant materials and honey used were sourced locally. The herbal mixture (STBH) was formulated from Sorghum bicolor L., (7.74g/kg body weight), Tumeric (2.4 g/kg body weight), Honey (2.5 g/kg body weight) and Bridelia ferruginea (0.4 g/kg body weight) to form 13 g/kg body weight (1.3 mg/g) of the mixture. A total of 40, apparently healthy male Wistar rats, 6-8weeks old with average initial body weight of 75 g was used. The rats were randomly grouped into four groups. The first 3 groups A, B and C (n=12 each) were orally administered the herbal mixture at dosage of 0.65mg/g, 1.3mg/g and 2.6mg/g of rat weight respectively for 28 days in order to determine the safe dose while the last group D (n=4) as control. At the end of every week, the weights of the rats was measured, while the blood samples of 3 rats per treatment group and one from control group which were randomly selected were subjected to Biochemical and Haematological assays and their organs (Kidney, Heart and Liver) were harvested for histological examination following standard methods. The results revealed weight gain among the rat fed with STBH compared to the control rats with group A having the highest percentage weight gain (50.55%). Haematological results showed significant (p<0.05) improvement in pack cell volume (PCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular volume (MCV) of the rats. Moreover, significant (p<0.05) immunostimulatory effect was observed in group A rats compared to groups B, C and D rats. AST and ALT were considerably lower in group A rats when compared to the control, unlike the increase in values at higher dosages (groups B and C rats) though the increase was not significant (p>0.05) . Urea level was fairly high in groups B and C rats, while it reduced in group A rats as compared to the control group. Histology of the liver, heart and kidney of the rats fed with STBH showed near normal architecture with no significant deviations from the control. These suggest that STBH is safe, improves PCV, has immunostimulatory potential and also shows ability to maintain the normal architecture of the liver, kidney and the heart.