The author reports on a patient a case of severe metallosis in total knee replacement. Wear of total knee replacement continues to be a significant factor influencing the clinical longevity of implants. Here we present a case of a 63-year-old female who had undergone total knee arthroplasty 15 years ago and developed implant loosening associated with severe metallosis and varus instability the metallic debris leads to a massive local and systemic release of cytokines. This patient was subjected to revision surgery consisting of thorough debridement and primary implant replacement by a hinged endoprosthesis.
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