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As an emerging form of online display advertising, in-feed native advertising is increasingly employed in online news feed platforms. While many advertisers have largely embraced this new advertising format, the current research is full of controversy on whether the more native, the better the effect of in-feed native advertising. Based on recent studies on this emerging topic, the authors explore the effective in-feed native advertising persuasion strategies based on consumers’ dynamic online browsing modes. In study 1, the authors conducted an archived-data analysis (in co-operation with Baidu company). Results show that the match between in-feed native advertising persuasion style (implicit vs. explicit) and consumers’ real-time news feed browsing modes (convergent vs. divergent) can improve ad performance. In study 2, the authors further explained why consumers under different browsing modes respond differently (the mediation effect of self-agency vs. external agency) to specific in-feed native advertising persuasion. Our work explores the boundaries of agency theory from a dynamic perspective and helps advertisers conduct real-time and effective targeting strategies.

Objective: Receptor for advanced glycation end products (RAGE), along with its ligand high mobility group box 1 (HMGB1), is believed to play an important role in prostate cancer. The aim of this retrospective study was to investigate the expression of RAGE and HMGB1 and their clinical impact on prostate cancer progression and prognosis. Methods: The expression of RAGE and HMGB1 were assessed by immunohistochemistry in cancer lesions from 85 confirmed prostate cancer cases. We determined the potential association between the expression level of these two proteins and the clinicopathological features and overall patient survival. Results: The RAGE and HMGB1 were expressed in 78.8% (67/85) and 68.2% (58/85) cases of prostate cancers, respectively, and in the majority (54/85) of cases, these two proteins were co-expressed. There was a strong correlation between RAGE and HMGB1 expressions (P<0.001). The expression of RAGE, HMGB1 and their co-expression were all associated with advanced tumor clinical stage (P<0.05 for all). RAGE expression was also associated with the prostate specific antigen (PSA) level (P=0.014). However, neither the individual expression of those genes nor their co-expression was significantly related with age and Gleason score. The co-expression of RAGE and HMGB1 was associated with poor overall survival in patients with stage III and IV prostate cancer (P=0.047). Conclusions: These results suggest that the expression of RAGE and HMGB1 is associated with the progression and poor prognosis of prostate cancer. RAGE and HMGB1 could be new prognostic biomarkers for prostate cancer as well as molecular target for novel forms of therapies. AB125. The correlation of SRSF1 and survivin in prostate cancer Bangming Xiao, Ping WangThe Fourth Affiliated Hospital of China Medical University, Shenyang 110005, ChinaObjective: To test the expression of serine/arginine rich splicing factor 1 (SRSF1) and survivin [poptosis inhibiting factor (survivin)] in prostate cancer organizations, and study their correlation with the pathological features of prostate cancer, thus put forward the new targets in the treatment of prostate cancer. Methods: SRSF1, survivin protein was analyzed in 20 prostate tissue samples including prostate cancer and benign prostatic hyperplasia by immunohistochemical SP method. SRSF1, survivin was correlated to pathological features, and both the relevance was analyzed (no related reports at home and abroad). Results: The positive expression rate of SRSF1 protein in prostate cancer tissue cells was 76.37%±5.06%, significantly higher than that of benign prostatic hyperplasia 11.30%+1.09% (P<0.05); the positive expression rate of survivin protein in prostate cancer tissue cells was 86.93%±3.21%, significantly higher than that of benign prostatic hyperplasia 17.67%±1.99% (P<0.05); SRSF1 and survivin protein expressed in prostate cancer organizations and were positively correlated to pathological Gleason grading, and the second Have significant correlation (P<0.05). Conclusions: SRSF1 and survivi...